Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart

Yu B. Lishmanov, L. N. Maslov, A. V. Krylatov, N. V. Solenkova, D. L. Stakheev

Результат исследований: Материалы для журналаСтатьярецензирование

2 Цитирования (Scopus)

Аннотация

During aconitine-induced arrhythmias the antiarrhythmic effect of DALDA (Tyr-D-Arg-Phe-Lys-NH2) and nociceptin (orphanin FQ) administered intravenously depended on activation of nitric oxide synthase. KATP channels were not involved in the realization of this effect. Endogenous prostanoids played a minor role in the antiarrhythmic effect of nociceptin and did not contribute to the protective influence of DALDA. The antiarrhythmic effect of orphanin FQ administered intravenously did not depend on functional activity of the autonomic nervous system. However, the effect of orphanin FQ after intracerebroventricular infusion was determined by changes in the state of this system.

Язык оригиналаАнглийский
Страницы (с-по)55-58
Число страниц4
ЖурналBulletin of Experimental Biology and Medicine
Том135
Номер выпуска1
DOI
СостояниеОпубликовано - 1 янв 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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