Porphyrin‑silver nanoparticles hybrids: Synthesis, characterization and antibacterial activity

R. Elashnikov, M. Radocha, I. Panov, S. Rimpelova, P. Ulbrich, A. Michalcova, V. Svorcik, O. Lyutakov

Результат исследований: Материалы для журналаСтатья

6 Цитирования (Scopus)


The preparation of light-activated hybrid antibacterial agent combining the porphyrin molecules, bound to the silver nanoparticles (AgNPs) surface is reported. AgNPs were synthesized by N-methyl-2-pyrrolidone-initiated reduction without additional reducing agents. The chemical structure of protoporphyrin IX was modified with the aim to introduce thiol groups. The size distribution and shape features of AgNPs were checked using TEM and HRTEM microscopies. The introduction of thiol groups into the porphyrin was proved by IR spectroscopy. The AgNPs-porphyrin binding was performed in solution and confirmed by fluorescence quenching, Raman spectroscopy and energy-filtered transmission electron microscopy (EFTEM). The antibacterial tests were performed against S. epidermidis and E. coli upon to LED illumination and in the dark. The synergetic effect of AgNPs and porphyrin as well as light activation of the created antibacterial conjugates were observed.

Язык оригиналаАнглийский
Страницы (с-по)192-199
Число страниц8
ЖурналMaterials Science and Engineering C
СостояниеОпубликовано - 1 сен 2019
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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