Polymer capsules modified with iron oxide nanoparticles as an effective platform for MRI visualization and drug delivery

L. I. Fatkhutdinova, A. Andreychenko, E. Brui, A. S. Timin, G. E. Pavlovskaya, A. N. Khlobystov, M. V. Zyuzin

Результат исследований: Материалы для журнала

Аннотация

Efficiency of existing (usually toxic) drugs can be increased substantially with the targeted effect on the site of the disease. A potential platform for the targeted drug delivery can be polymer capsules. This will help reduce side effects on the human body and start treatment at the early stages of the disease. Modification of such capsules with the magnetic nanoparticles allows their visualization using magnetic resonance imaging (MRI). In this study the use of polymer microcapsules modified with iron oxide nanoparticles are employed as contrast agents for T2-weighted magnetic resonance (MR) images, the possibility of their implementation as for drug delivery carriers are discussed. For this, two different types of polymer capsules are synthesized. The results on the spin-spin and spin-lattice relaxivities were obtained.

Язык оригиналаАнглийский
Номер статьи012037
ЖурналJournal of Physics: Conference Series
Том1461
Номер выпуска1
DOI
СостояниеОпубликовано - 23 апр 2020
Событие4th International Conference on Metamaterials and Nanophotonics, METANANO 2019 - St. Petersburg, Российская Федерация
Продолжительность: 15 июл 201919 июл 2019

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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