Platinum derivative effect on activity of microsomal NADPH-oxidoreductases

I. A. Shchepetkin, V. M. Plotnikov, V. T. Kagiya

Результат исследований: Материалы для журналаСтатьярецензирование

1 Цитирования (Scopus)

Аннотация

The influence of platinum derivatives, cisplatin (cis-diamminedichloroplatinum) and imidazolplatin (cis-diimidazoledichloroplatinum) on the activity of rat liver microsomal NADPH-oxidoreductases was investigated in vitro using spectrophotometrical and chemiluminometrical methods. In the range of concentrations from 1 to 12 μM cisplatin inhibited NADPH-cytochrome c-reductase activity and NADPH/lucigenin-dependent chemiluminescence of microsomes. The 3 μM cisplatin decreased the NADPH-dependent reductase activity by 50%. At concentrations less than 2,5 mM sanazole (drug AK-2123) did not prevent the inhibiting influence of cisplatin on microsomal NADPH-dependent reductases. Imidazolplatin insignificantly inhibited NADPH-reductases. It is concluded that negligible inhibiting effect of imidazolplatin on microsomal NADPH-oxidoreductase allows us to consider, this platinum derivative as a promising compound for further experimental trials as anticancer drug with low toxic action on the normal tissues of an organism.

Язык оригиналаАнглийский
Страницы (с-по)380-381
Число страниц2
ЖурналVoprosy Meditsinskoj Khimii
Том47
Номер выпуска4
СостояниеОпубликовано - 2001
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Clinical Biochemistry
  • Molecular Biology
  • Pharmacology

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