Perspective of creation of drugs on basis of opioids increasing cardiac tolerance to pathogenic impact of ischemia reperfusion

L. N. Maslov, Yu B. Lishmanov, J. P. Headrick, J. M. Pei, L. Hanuš, A. V. Krylatov, N. V. Naryzhnaya

Результат исследования: Материалы для журналаСтатья

2 Цитирования (Scopus)

Аннотация

It was established that δ- and K1-opioid receptor (OR) stimulation both in vivo and in vitro promotes a decrease of infarct size/area at risk (IS/AAR) ratio during ischemia and reperfusion of heart. μ-OR activation increases a tolerance of isolated perfused heart to impact of ischemia and reperfusion but has no effect on IS/AAR index in vivo. The ORL1-receptor agonist nociceptin does not exert IS/AAR ratio in vivo. δ- and κ1-OR stimulation prevents cardiomyocyte apoptosis during ischemia and reperfiision of heart. The δ- and κ1-OR agonists mimic infarct-reducing effect of postconditioning. The OR inhibition does not impact IS/AAR index both in vivo and in vitro. The δ1- , δ2- and κ1-OR agonists are the most perspective group of opioids for creation of drugs increasing cardiac tolerance to pathogenic impact of ischemia and reperfusion.

Язык оригиналаАнглийский
Страницы (с... по...)22-28
Количество страниц7
ЖурналEksperimental'naya i Klinicheskaya Farmakologiya
Том75
Номер выпуска10
Статус публикацииОпубликовано - 2012

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ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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