Oxygen Metabolism in the Lung

Andrew J. Gow, Henry J. Forman

Результат исследований: Материалы для книги/типы отчетовГлава

Выдержка

Although most of the O2 delivered to the lung diffuses into the blood and is ultimately utilized by other tissues, the lung itself requires O2 for both energy metabolism and cellular signaling. The greatest use of O2 by lung cells, as typical cells, is in the generation of adenosine triphosphate (ATP). For this reason, we will focus a large part of this discussion on the mechanisms for generating ATP, rather than just on the more narrow area of cytochrome c oxidase activity. The lung is also the site of a number of other important biochemical roles for O2. These include the transformation of steroids and xenobiotics by cytochrome P450 and flavin monooxygenase; the production of nitric oxide; the oxidation of amines, such as serotonin; the formation of collagen and elastin cross-links by oxidative processes; the production of prostaglandins, leukotrienes, and related arachidonate metabolites; and the oxidative killing of microorganisms by phagocytes. Oxygen is used to generate hydrogen peroxide for cell signaling. While low in quantitative terms, this oxygen consumption, primarily from nicotinamide adenine dinucleotide phosphate oxidases and possibly by mitochondria, is very significant physiologically. Finally, we will briefly consider the role of enzymes involved with eliminating the toxic byproducts of the reactions listed above. Our primary aim here, however, is to describe the normal O2 metabolism of the lung.

Язык оригиналаАнглийский
Название основной публикацииComparative Biology of the Normal Lung: Second Edition
ИздательElsevier Inc.
Страницы355-374
Число страниц20
ISBN (электронное издание)9780124045774
ISBN (печатное издание)9780124047266
DOI
СостояниеОпубликовано - 18 мар 2015
Опубликовано для внешнего пользованияДа

Отпечаток

Oxygen
Lung
Adenosine Triphosphate
Elastin
Leukotrienes
Poisons
Xenobiotics
Electron Transport Complex IV
Phagocytes
Mixed Function Oxygenases
NADP
Oxygen Consumption
Cytochrome P-450 Enzyme System
Hydrogen Peroxide
Energy Metabolism
Prostaglandins
Amines
Serotonin
Mitochondria
Oxidoreductases

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Цитировать

Gow, A. J., & Forman, H. J. (2015). Oxygen Metabolism in the Lung. В Comparative Biology of the Normal Lung: Second Edition (стр. 355-374). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-404577-4.00018-7

Oxygen Metabolism in the Lung. / Gow, Andrew J.; Forman, Henry J.

Comparative Biology of the Normal Lung: Second Edition. Elsevier Inc., 2015. стр. 355-374.

Результат исследований: Материалы для книги/типы отчетовГлава

Gow, AJ & Forman, HJ 2015, Oxygen Metabolism in the Lung. в Comparative Biology of the Normal Lung: Second Edition. Elsevier Inc., стр. 355-374. https://doi.org/10.1016/B978-0-12-404577-4.00018-7
Gow AJ, Forman HJ. Oxygen Metabolism in the Lung. В Comparative Biology of the Normal Lung: Second Edition. Elsevier Inc. 2015. стр. 355-374 https://doi.org/10.1016/B978-0-12-404577-4.00018-7
Gow, Andrew J. ; Forman, Henry J. / Oxygen Metabolism in the Lung. Comparative Biology of the Normal Lung: Second Edition. Elsevier Inc., 2015. стр. 355-374
@inbook{93c6aa206beb45d2ae34a61844089a9d,
title = "Oxygen Metabolism in the Lung",
abstract = "Although most of the O2 delivered to the lung diffuses into the blood and is ultimately utilized by other tissues, the lung itself requires O2 for both energy metabolism and cellular signaling. The greatest use of O2 by lung cells, as typical cells, is in the generation of adenosine triphosphate (ATP). For this reason, we will focus a large part of this discussion on the mechanisms for generating ATP, rather than just on the more narrow area of cytochrome c oxidase activity. The lung is also the site of a number of other important biochemical roles for O2. These include the transformation of steroids and xenobiotics by cytochrome P450 and flavin monooxygenase; the production of nitric oxide; the oxidation of amines, such as serotonin; the formation of collagen and elastin cross-links by oxidative processes; the production of prostaglandins, leukotrienes, and related arachidonate metabolites; and the oxidative killing of microorganisms by phagocytes. Oxygen is used to generate hydrogen peroxide for cell signaling. While low in quantitative terms, this oxygen consumption, primarily from nicotinamide adenine dinucleotide phosphate oxidases and possibly by mitochondria, is very significant physiologically. Finally, we will briefly consider the role of enzymes involved with eliminating the toxic byproducts of the reactions listed above. Our primary aim here, however, is to describe the normal O2 metabolism of the lung.",
keywords = "Antioxidants, Cytochrome P450, Dioxygenase, Mitochondria, Monooxygenase, Oxidase, Oxidoreductase, Peroxide signaling",
author = "Gow, {Andrew J.} and Forman, {Henry J.}",
year = "2015",
month = "3",
day = "18",
doi = "10.1016/B978-0-12-404577-4.00018-7",
language = "English",
isbn = "9780124047266",
pages = "355--374",
booktitle = "Comparative Biology of the Normal Lung: Second Edition",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - Oxygen Metabolism in the Lung

AU - Gow, Andrew J.

AU - Forman, Henry J.

PY - 2015/3/18

Y1 - 2015/3/18

N2 - Although most of the O2 delivered to the lung diffuses into the blood and is ultimately utilized by other tissues, the lung itself requires O2 for both energy metabolism and cellular signaling. The greatest use of O2 by lung cells, as typical cells, is in the generation of adenosine triphosphate (ATP). For this reason, we will focus a large part of this discussion on the mechanisms for generating ATP, rather than just on the more narrow area of cytochrome c oxidase activity. The lung is also the site of a number of other important biochemical roles for O2. These include the transformation of steroids and xenobiotics by cytochrome P450 and flavin monooxygenase; the production of nitric oxide; the oxidation of amines, such as serotonin; the formation of collagen and elastin cross-links by oxidative processes; the production of prostaglandins, leukotrienes, and related arachidonate metabolites; and the oxidative killing of microorganisms by phagocytes. Oxygen is used to generate hydrogen peroxide for cell signaling. While low in quantitative terms, this oxygen consumption, primarily from nicotinamide adenine dinucleotide phosphate oxidases and possibly by mitochondria, is very significant physiologically. Finally, we will briefly consider the role of enzymes involved with eliminating the toxic byproducts of the reactions listed above. Our primary aim here, however, is to describe the normal O2 metabolism of the lung.

AB - Although most of the O2 delivered to the lung diffuses into the blood and is ultimately utilized by other tissues, the lung itself requires O2 for both energy metabolism and cellular signaling. The greatest use of O2 by lung cells, as typical cells, is in the generation of adenosine triphosphate (ATP). For this reason, we will focus a large part of this discussion on the mechanisms for generating ATP, rather than just on the more narrow area of cytochrome c oxidase activity. The lung is also the site of a number of other important biochemical roles for O2. These include the transformation of steroids and xenobiotics by cytochrome P450 and flavin monooxygenase; the production of nitric oxide; the oxidation of amines, such as serotonin; the formation of collagen and elastin cross-links by oxidative processes; the production of prostaglandins, leukotrienes, and related arachidonate metabolites; and the oxidative killing of microorganisms by phagocytes. Oxygen is used to generate hydrogen peroxide for cell signaling. While low in quantitative terms, this oxygen consumption, primarily from nicotinamide adenine dinucleotide phosphate oxidases and possibly by mitochondria, is very significant physiologically. Finally, we will briefly consider the role of enzymes involved with eliminating the toxic byproducts of the reactions listed above. Our primary aim here, however, is to describe the normal O2 metabolism of the lung.

KW - Antioxidants

KW - Cytochrome P450

KW - Dioxygenase

KW - Mitochondria

KW - Monooxygenase

KW - Oxidase

KW - Oxidoreductase

KW - Peroxide signaling

UR - http://www.scopus.com/inward/record.url?scp=84939618504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939618504&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-404577-4.00018-7

DO - 10.1016/B978-0-12-404577-4.00018-7

M3 - Chapter

AN - SCOPUS:84939618504

SN - 9780124047266

SP - 355

EP - 374

BT - Comparative Biology of the Normal Lung: Second Edition

PB - Elsevier Inc.

ER -