Opiatergic mechanisms of cardioprotective and antiarrhythmic effects of adaptation

Yu B. Lishmanov, L. A. Maimeskulova, E. V. Uskina, L. N. Maslov

Результат исследований: Материалы для журналаСтатьярецензирование

1 Цитирования (Scopus)

Аннотация

Adaptation to hypoxia and short-term immobilization stress, as well as preconditioning with Rhodiolae rosea extract produces pronounced antiarrhythmic and cardioprotective effects in the model of adrenergic damage to the heart. Preliminary blockade of opioid receptor significantly decreases the protective effect of adaptation. Using selective opiate receptor antagonists (naltrindole, ICI 174,864, and norbinaltorphimine) we show that the antiarrhythmic effect of adaptation is mediated predominantly via activation of κ-receptors, and to a lesser extent μ- and δ-receptors.

Язык оригиналаАнглийский
Страницы (с-по)151-154
Число страниц4
ЖурналBulletin of Experimental Biology and Medicine
Том127
Номер выпуска2
СостояниеОпубликовано - фев 1999

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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