Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: Physiochemical and microcomputer tomographical characterization

Timothy E.L. Douglas, Josefien Schietse, Aneta Zima, Svetlana Gorodzha, Bogdan V. Parakhonskiy, Dmitry KhaleNkow, Roman Shkarin, Anna Ivanova, Tilo Baumbach, Venera Weinhardt, Christian V. Stevens, Valérie Vanhoorne, Chris Vervaet, Lieve Balcaen, Frank Vanhaecke, Anna Slośarczyk, Maria A. Surmeneva, Roman A. Surmenev, Andre G. Skirtach

Результат исследований: Материалы для журналаСтатья

19 Цитирования (Scopus)

Аннотация

Mineralized hydrogels are increasingly gaining attention as biomaterials for bone regeneration. The most common mineralization strategy has been addition of preformed inorganic particles during hydrogel formation. This maintains injectability. One common form of bone cement is formed by mixing particles of the highly reactive calcium phosphate alpha-tricalcium phosphate (α-TCP) with water to form hydroxyapatite (HA). The calcium ions released during this reaction can be exploited to crosslink anionic, calcium-binding polymers such as the polysaccharide gellan gum (GG) to induce hydrogel formation. In this study, three different amounts of α-TCP particles were added to GG polymer solution to generate novel, injectable hydrogel-inorganic composites. Distribution of the inorganic phase in the hydrogel was studied by high resolution microcomputer tomography (µCT). Gelation occurred within 30 min. α-TCP converted to HA. µCT revealed inhomogeneous distribution of the inorganic phase in the composites. These results demonstrate the potential of the composites as alternatives to traditional α-TCP bone cement and pave the way for incorporation of biologically active substances and in vitro and in vivo testing.

Язык оригиналаАнглийский
Страницы (с-по)822-828
Число страниц7
ЖурналJournal of Biomedical Materials Research - Part A
Том106
Номер выпуска3
DOI
СостояниеОпубликовано - 1 мар 2018

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Fingerprint Подробные сведения о темах исследования «Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: Physiochemical and microcomputer tomographical characterization». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать

    Douglas, T. E. L., Schietse, J., Zima, A., Gorodzha, S., Parakhonskiy, B. V., KhaleNkow, D., Shkarin, R., Ivanova, A., Baumbach, T., Weinhardt, V., Stevens, C. V., Vanhoorne, V., Vervaet, C., Balcaen, L., Vanhaecke, F., Slośarczyk, A., Surmeneva, M. A., Surmenev, R. A., & Skirtach, A. G. (2018). Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: Physiochemical and microcomputer tomographical characterization. Journal of Biomedical Materials Research - Part A, 106(3), 822-828. https://doi.org/10.1002/jbm.a.36277