Novel concepts of "niche-relief" and "niche-voltage" for stem cells as a base of bone and hematopoietic tissues biomimetic engineering

Igor Albertovich Khlusov, Yu Dekhtyar, M. Yu Khlusova, E. A. Gostischev, Yu P. Sharkeev, V. F. Pichugin, E. V. Legostaeva

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

9 Цитирования (Scopus)

Аннотация

An affect of relief features and quantitative variables of artificial surfaces on structural-functional status of human lung prenatal stromal cells (HLPSC) and remodeling of Balb/c mice bone/bone marrow system have been studied. Implants with rough (Ra>2 μm) calcium phosphate micro-arc coatings have structural-functional sites (micro-regions) named "niches-relief" which are necessary for maturation and differentiation of HLPSC into secreting osteoblasts in shortterm culture. Maximal remodeling of mouse bone/bone marrow system in 45-day subcutaneous heterotopic test in vivo is also noted under optimal parameter (average index of cellular alkaline phosphatase area to artificial micro-region area is about 43 %) of osteogenic niche in vitro. Probable physical mechanism of osteogenic niche functioning has been determined. It correlates with increasing of electron work function supplied with a negative charge of calcium phosphate nanorelief in the sockets (artificial "niches"). "Niche-voltage" concept for bone tissue biomimetic engineering was proposed.

Язык оригиналаАнглийский
Название основной публикацииIFMBE Proceedings
Страницы99-102
Число страниц4
Том38 IFMBE
DOI
СостояниеОпубликовано - 2013
СобытиеInternational Symposium on Biomedical Engineering and Medical Physics, ISBEMP 2012 - Riga, Латвия
Продолжительность: 10 окт 201212 окт 2012

Другое

ДругоеInternational Symposium on Biomedical Engineering and Medical Physics, ISBEMP 2012
СтранаЛатвия
ГородRiga
Период10.10.1212.10.12

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

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