No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia

Svetlana A. Ivanova, Asmar F Y Al Hadithy, Natalia Brazovskaya, Arkadiy Semke, Bob Wilffert, Olga Fedorenko, Jacobus R B J Brouwers, Anton J M Loonen

Результат исследований: Материалы для журналаСтатья

8 Цитирования (Scopus)

Аннотация

Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia.

Язык оригиналаАнглийский
Страницы (с-по)334-337
Число страниц4
ЖурналHuman Psychopharmacology
Том27
Номер выпуска3
DOI
СостояниеОпубликовано - мая 2012

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Pharmacology (medical)

Fingerprint Подробные сведения о темах исследования «No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать

    Ivanova, S. A., Al Hadithy, A. F. Y., Brazovskaya, N., Semke, A., Wilffert, B., Fedorenko, O., Brouwers, J. R. B. J., & Loonen, A. J. M. (2012). No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia. Human Psychopharmacology, 27(3), 334-337. https://doi.org/10.1002/hup.2226