New antirheumatic substance based on phenolic glycoside structure methyl (4-O-B-glucopyranosyloxy)-benzoic acid

Nemtsev Alexey, Smirnov Ivan, Murashko Tatyana, Ivanov Alexey, Bondarev Alex, Udut Vladimir

Результат исследований: Материалы для журналаСтатья

Аннотация

Rheumatoid arthritis (RA) is a chronic inflammatory multifactorial disorder affecting approximately 1% of population, with over 3000000 new cases annually. The principal pharmacological agents are nonsteroidal anti-inflammatory drugs (NSAID). Patients with rheumatoid arthritis are vulnerable to NSAID-associated gastrointestinal complications. Based on these findings we developed a new NSAID agent based on phenolic glycoside structure methyl (4-О-β-glucopyranosyloxy)-benzoic acid. In this study we evaluated the methyl (4-О-β-glucopyranosyloxy)-benzoic acid therapeutic effect in adjuvant-induced rat arthritis compared to etoricoxib effect. According to the results, methyl (4-О-β-glucopyranosyloxy)-benzoic acid activity was superior to etoricoxib, paw volume returned to the initial value 2 days early, than it did in etoricoxib group. Therefore, methyl (4-О-β-glucopyranosyloxy)-benzoic acid might contest to the modern antirheumatic drug etoricoxib.

Язык оригиналаАнглийский
Страницы (с-по)79-82
Число страниц4
ЖурналJurnal Teknologi
Том78
Номер выпуска6-8
DOI
СостояниеОпубликовано - 1 янв 2016

ASJC Scopus subject areas

  • Engineering(all)

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