Negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated via non-opioid receptors

L. N. Maslov, Yu B. Lishmanov, E. I. Barzakh, T. V. Lasukova, K. K. Rice, P. R. Oeltgen

Результат исследований: Материалы для журналаСтатья

7 Цитирования (Scopus)

Аннотация

Ten-minute perfusion of intact isolated rat heart with Krebs - Henseleit solution containing δ-opioid receptor agonists (DPDPE, (-)-TAN-67) or δ-opioid receptor antagonists (naltrindole, TIPP[ψ], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the rates of myocardial contraction and relaxation. Intravenous injection of δ-agonists (DPDPE, (-)-TAN-67, deltorphin II) or δ-antagonists (naltrindole, TIPP[ψ], ICI 174,864) decreased HR in narcotized rats. Naloxone and naltrexone produced no effect on contractility and HR both in vivo and in vitro. Preliminary injection of naloxone and naltrexone did not prevent the negative chronotropic effect of ICI 174,864 in vitro. The negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated by unknown non-opioid receptors in the heart.

Язык оригиналаАнглийский
Страницы (с-по)420-423
Число страниц4
ЖурналBulletin of Experimental Biology and Medicine
Том141
Номер выпуска4
DOI
СостояниеОпубликовано - 1 апр 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Подробные сведения о темах исследования «Negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated via non-opioid receptors». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать