Molecular mechanisms of action of bisphosphonates and strontium ranelate

A. I. Vengerovskii, Igor Albertovich Khlusov, K. A. Nechaev

Результат исследований: Материалы для журналаСтатья

2 Цитирования (Scopus)

Выдержка

Bisphosphonates are chemical analogs of isoprene lipids, which competitively decrease the activity of farnesyl diphosphate synthase in osteoclasts and thus retard prenylation. The non-prenylated small GTPases cannot attach to the membrane of osteoclasts, which decreases their resorptive function and accelerates apoptosis. Strontium ranelate activates the Wnt signal pathway (with participation of calcium-sensitive receptor), increases the replication activity (by changing the function of RANKL/RANK/OPG system) thus suppressing the apoptosis of osteoblasts, and retards the resorptive function by accelerating the apoptosis of osteoclasts.

Язык оригиналаАнглийский
Страницы (с-по)43-66
Число страниц24
ЖурналEksperimental'naya i Klinicheskaya Farmakologiya
Том77
Номер выпуска9
СостояниеОпубликовано - 2014
Опубликовано для внешнего пользованияДа

Отпечаток

strontium ranelate
Diphosphonates
Osteoclasts
Apoptosis
Geranyltranstransferase
Prenylation
Calcium-Sensing Receptors
Wnt Signaling Pathway
Monomeric GTP-Binding Proteins
Osteoblasts
Signal Transduction
Calcium
Membranes
Lipids

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Цитировать

Molecular mechanisms of action of bisphosphonates and strontium ranelate. / Vengerovskii, A. I.; Khlusov, Igor Albertovich; Nechaev, K. A.

В: Eksperimental'naya i Klinicheskaya Farmakologiya, Том 77, № 9, 2014, стр. 43-66.

Результат исследований: Материалы для журналаСтатья

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AU - Nechaev, K. A.

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AB - Bisphosphonates are chemical analogs of isoprene lipids, which competitively decrease the activity of farnesyl diphosphate synthase in osteoclasts and thus retard prenylation. The non-prenylated small GTPases cannot attach to the membrane of osteoclasts, which decreases their resorptive function and accelerates apoptosis. Strontium ranelate activates the Wnt signal pathway (with participation of calcium-sensitive receptor), increases the replication activity (by changing the function of RANKL/RANK/OPG system) thus suppressing the apoptosis of osteoblasts, and retards the resorptive function by accelerating the apoptosis of osteoclasts.

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