Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility

S. I. Tverdokhlebov, E. N. Bolbasov, E. V. Shesterikov, L. V. Antonova, A. S. Golovkin, V. G. Matveeva, Danila Gennadievich Petlin, Y. G. Anissimov

Результат исследований: Материалы для журналаСтатья

29 Цитирования (Scopus)

Аннотация

Surface modification of polylactic acid (PLLA) by plasma of radio-frequency magnetron discharge with hydroxyapatite target sputtering was investigated. Increased biocompatibility was demonstrated using studies with bone marrow multipotent mesenchymal stromal cells. Atomic force microscopy demonstrates that the plasma treatment modifies the surface morphology of PLLA to produce rougher surface. Infrared spectroscopy and X-ray diffraction revealed that changes in the surface morphology are caused by the processes of PLLA crystallization. Fluorescent X-ray spectroscopy showed that the plasma treatment also changes the chemical composition of PLLA, enriching it with ions of the sputtered target: calcium, phosphorus and oxygen. It is hypothesized that these surface modifications increase biocompatibility of PLLA without increasing toxicity.

Язык оригиналаАнглийский
Страницы (с-по)32-39
Число страниц8
ЖурналApplied Surface Science
Том329
DOI
СостояниеОпубликовано - 28 фев 2015

ASJC Scopus subject areas

  • Surfaces, Coatings and Films

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