Mediated role of NO-syntase protein kinase C and KATP-channels in realization of cardioprotective impact of cannabinoid HU-210

L. N. Maslov, O. V. Lasukova, A. V. Krylatov, L. Hanuš, Yu B. Lishmanov

Результат исследований: Материалы для журналаСтатья

2 Цитирования (Scopus)

Аннотация

It was shown that perfusion of the isolated heart of rat with solution containing the CB1- and CB2-receptor agonist HU-210 at concentrations of 0.1 or 1.0 μM/L for a duration of 10 min at 20 min before global ischemia (45 min) and reperfusion (30 min) promotes a twofold decrease in creatine kinase levels in coronary effluent. It was established that KATP channel blockade by glibenclamide (1 μM/L) or inhibition of protein kinase C (2 μM/L) by chelerythrine abolishes the cardioprotective effect of HU-210. The inhibitor of NO synthase L-NAME (1 μM/L) had no effect on the anti-necrotic effect of HU-210. Thus, the intracellular signaling mechanism of the cardioprotective effect of the CB-agonist HU-210 involves the activation of KATP channels and protein kinase C without the participation of NO-synthase.

Язык оригиналаАнглийский
Страницы (с-по)15-18
Число страниц4
ЖурналEksperimental'naya i Klinicheskaya Farmakologiya
Том75
Номер выпуска12
СостояниеОпубликовано - 2012

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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