Luminescence monitoring of particle delivery into rat skin in vivo

E. K. Volkova, I. Y. Yanina, E. A. Genina, L. E. Dolotov, A. N. Bashkatov, V. D. Genin, J. G. Konyukhova, A. P. Popov, M. D. Kozintseva, E. Speranskaya, M. Lomova, G. S. Terentyuk, A. B. Bucharskaya, N. A. Navolokin, I. Y. Goryacheva, V. I. Kochubey, D. A. Gorin, V. V. Tuchin, G. B. Sukhorukov

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

4 Цитирования (Scopus)


Delivery of upconversion microparticles [Y2O3:Yb, Er] and quantum dots (CuInS2/ZnS coated with PEG-based amphiphilic polymer) into rat skin using the fractional laser microablation has been studied in vivo. Luminescence spectroscopy, optical coherence tomography, confocal microscopy, and histochemical analysis were used for visualization of nanoparticles in microchannels. Results have shown that the upconversion microparticles are detected more efficiently in comparison with the quantum dots. The fluorescence intensity of the inserted upconversion microparticles is higher, when the Omnipaque™ was applied as a skin optical clearing agent. The fluorescent images of upconversion nanoparticle distribution indicate the advantage of particle delivery into skin by ultrasound.

Язык оригиналаАнглийский
Название основной публикацииClinical and Biomedical Spectroscopy and Imaging IV
ISBN (электронное издание)9781628417029
СостояниеОпубликовано - 2015
Опубликовано для внешнего пользованияДа
СобытиеClinical and Biomedical Spectroscopy and Imaging IV - Munich, Германия
Продолжительность: 22 июн 201524 июн 2015


КонференцияClinical and Biomedical Spectroscopy and Imaging IV


ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


Volkova, E. K., Yanina, I. Y., Genina, E. A., Dolotov, L. E., Bashkatov, A. N., Genin, V. D., Konyukhova, J. G., Popov, A. P., Kozintseva, M. D., Speranskaya, E., Lomova, M., Terentyuk, G. S., Bucharskaya, A. B., Navolokin, N. A., Goryacheva, I. Y., Kochubey, V. I., Gorin, D. A., Tuchin, V. V., & Sukhorukov, G. B. (2015). Luminescence monitoring of particle delivery into rat skin in vivo. В Clinical and Biomedical Spectroscopy and Imaging IV (Том 9537). [95371P] SPIE.