Lucigenin luminescence elicited by microsomes and its modulation by nitroazole compounds

Результат исследований: Материалы для журналаСтатья

2 Цитирования (Scopus)

Аннотация

The lucigenin luminescence elicited by rat liver microsomes and its modulation by the nitroazole compounds metronidazole and sanazole (drug AK- 2123), as well as the rates of lucigen-independent NADPH consumption and cytochrome c reduction, were studied. The obtained data suggest that the luminescence can be the result of univalent lucigenin reduction by microsomal NAD(P)H-reductases, generation of superoxide anion radical in the redox cycle of lucigenin radicals, dioxetane formation by (di)oxygenases, and catalytic action of cytochrome P450 heme on dioxetane decomposition, followed by light emission.

Язык оригиналаАнглийский
Страницы (с-по)499-504
Число страниц6
ЖурналIUBMB Life
Том48
Номер выпуска5
СостояниеОпубликовано - 1999
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Genetics
  • Molecular Biology

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