Liver uptake of radiolabeled targeting proteins and peptides: Considerations for targeting peptide conjugate design

Seyed Jalal Hosseinimehr, Vladimir Tolmachev, Anna Orlova

Результат исследований: Материалы для журналаОбзорная статьярецензирование

50 Цитирования (Scopus)

Аннотация

Radionuclide imaging of molecular targets for cancer therapy is likely to be a powerful tool for patient stratification and response monitoring, allowing more personalized cancer treatment. Radiolabeled proteins and peptides are a promising class of imaging probes for visualization of molecular targets in vivo. However, hepatic uptake and hepatobiliary excretion of radioactivity can decrease imaging contrast, reducing the detection sensitivity of hepatic and extrahepatic abdominal metastases, respectively. In this article, we review factors that influence the hepatic uptake of radioactivity (e.g. the chemical nature of radiocatabolites and physicochemical properties of targeting peptides and linkers) to provide input for the rational design of peptide-based imaging probes.

Язык оригиналаАнглийский
Страницы (с-по)1224-1232
Число страниц9
ЖурналDrug Discovery Today
Том17
Номер выпуска21-22
DOI
СостояниеОпубликовано - ноя 2012
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint Подробные сведения о темах исследования «Liver uptake of radiolabeled targeting proteins and peptides: Considerations for targeting peptide conjugate design». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать