Liposomes loaded with hydrophilic magnetite nanoparticles: Preparation and application as contrast agents for magnetic resonance imaging

S. V. German, N. A. Navolokin, N. R. Kuznetsova, V. V. Zuev, O. A. Inozemtseva, A. A. Anis'kov, E. K. Volkova, A. B. Bucharskaya, G. N. Maslyakova, R. F. Fakhrullin, G. S. Terentyuk, E. L. Vodovozova, D. A. Gorin

Результат исследований: Материалы для журналаСтатья

44 Цитирования (Scopus)

Аннотация

Magnetic fluid-loaded liposomes (MFLs) were fabricated using magnetite nanoparticles (MNPs) and natural phospholipids via the thin film hydration method followed by extrusion. The size distribution and composition of MFLs were studied using dynamic light scattering and spectrophotometry. The effective ranges of magnetite concentration in MNPs hydrosol and MFLs for contrasting at both T2 and T1 relaxation were determined. On T2 weighted images, the MFLs effectively increased the contrast if compared with MNPs hydrosol, while on T1 weighted images, MNPs hydrosol contrasting was more efficient than that of MFLs. In vivo magnetic resonance imaging (MRI) contrasting properties of MFLs and their effects on tumor and normal tissues morphology, were investigated in rats with transplanted renal cell carcinoma upon intratumoral administration of MFLs. No significant morphological changes in rat internal organs upon intratumoral injection of MFLs were detected, suggesting that the liposomes are relatively safe and can be used as the potential contrasting agents for MRI.

Язык оригиналаАнглийский
Страницы (с-по)109-115
Число страниц7
ЖурналColloids and Surfaces B: Biointerfaces
Том135
DOI
СостояниеОпубликовано - 1 ноя 2015
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

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  • Цитировать

    German, S. V., Navolokin, N. A., Kuznetsova, N. R., Zuev, V. V., Inozemtseva, O. A., Anis'kov, A. A., Volkova, E. K., Bucharskaya, A. B., Maslyakova, G. N., Fakhrullin, R. F., Terentyuk, G. S., Vodovozova, E. L., & Gorin, D. A. (2015). Liposomes loaded with hydrophilic magnetite nanoparticles: Preparation and application as contrast agents for magnetic resonance imaging. Colloids and Surfaces B: Biointerfaces, 135, 109-115. https://doi.org/10.1016/j.colsurfb.2015.07.042