TY - JOUR
T1 - Label-Free Electrochemical Biosensors for the Determination of Flaviviruses
T2 - Dengue, Zika, and Japanese Encephalitis
AU - Khristunova, Ekaterina
AU - Dorozhko, Elena
AU - Korotkova, Elena
AU - Kratochvil, Bohumil
AU - Vyskocil, Vlastimil
AU - Barek, Jiri
PY - 2020/8/16
Y1 - 2020/8/16
N2 - A highly effective way to improve prognosis of viral infectious diseases and to determine the outcome of infection is early, fast, simple, and efficient diagnosis of viral pathogens in biological fluids. Among a wide range of viral pathogens, Flaviviruses attract a special attention. Flavivirus genus includes more than 70 viruses, the most familiar being dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV). Haemorrhagic and encephalitis diseases are the most common severe consequences of flaviviral infection. Currently, increasing attention is being paid to the development of electrochemical immunological methods for the determination of Flaviviruses. This review critically compares and evaluates recent research progress in electrochemical biosensing of DENV, ZIKV, and JEV without labelling. Specific attention is paid to comparison of detection strategies, electrode materials, and analytical characteristics. The potential of so far developed biosensors is discussed together with an outlook for further development in this field.
AB - A highly effective way to improve prognosis of viral infectious diseases and to determine the outcome of infection is early, fast, simple, and efficient diagnosis of viral pathogens in biological fluids. Among a wide range of viral pathogens, Flaviviruses attract a special attention. Flavivirus genus includes more than 70 viruses, the most familiar being dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV). Haemorrhagic and encephalitis diseases are the most common severe consequences of flaviviral infection. Currently, increasing attention is being paid to the development of electrochemical immunological methods for the determination of Flaviviruses. This review critically compares and evaluates recent research progress in electrochemical biosensing of DENV, ZIKV, and JEV without labelling. Specific attention is paid to comparison of detection strategies, electrode materials, and analytical characteristics. The potential of so far developed biosensors is discussed together with an outlook for further development in this field.
KW - electrochemical biosensors
KW - Flavivirus
KW - label-free
UR - http://www.scopus.com/inward/record.url?scp=85089805028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089805028&partnerID=8YFLogxK
U2 - 10.3390/s20164600
DO - 10.3390/s20164600
M3 - Review article
C2 - 32824351
AN - SCOPUS:85089805028
VL - 20
JO - Sensors
JF - Sensors
SN - 1424-3210
IS - 16
ER -