Janus glycosides of next generation: Synthesis of 4-(3-chloropropoxy)phenyl and 4-(3-azidopropoxy)phenyl glycosides

Elena V. Stepanova, Polina I. Abronina, Alexander I. Zinin, Alexander O. Chizhov, Leonid O. Kononov

Результат исследований: Материалы для журналаСтатья

1 Цитирования (Scopus)

Аннотация

Efficient procedures for the preparative synthesis of per-O-acyl derivatives of 4-(3-chloropropoxy)phenyl (CPP) glycosides of a series of common mono- and disaccharides (D-glucose, D-galactose, D-mannose, L-rhamnose, D-arabinofuranose, D-glucosamine, lactose) are described. The CPP glycosides obtained were transformed in almost quantitative yields to the corresponding unprotected 4-(3-azidopropoxy)phenyl (APP) glycosides, which could become next-generation Janus glycosides with cleavable spacer aglycon, ready for conjugation or further transformation.

Язык оригиналаАнглийский
Страницы (с-по)95-104
Число страниц10
ЖурналCarbohydrate Research
DOI
СостояниеОпубликовано - 1 янв 2019

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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