Investigation of new nsaids for the treatment of inflammatory diseases of kidney and urinary tract

Murashko Tatyana, Ivanov Alexey, Smirnov Ivan, Bondarev Alex, Alexey Nemtsev, Udut Vladimir

Результат исследований: Материалы для журналаСтатья

Аннотация

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the world, primarily due to their high efficiency for the treatment of inflammatory induced pain syndrome. The main feature of NSAIDs is a combination of anti-inflammatory, analgesic, antipyretic, and anticoagulant properties. However, their long-term use is associated with side effects in the gastrointestinal tract including peptic ulcers and other. We developed and synthesized molecule of methyl (4-О-β-glucopyranosyloxy)-benzoic acid. The anti-inflammatory effect of methyl (4-О-β-glucopyranosyloxy)-benzoic acid evaluated using the carrageenan-induced hindpaw edema model. The study shows that the intragastrically administration of test substance to animals reduces inflammatory process.

Язык оригиналаАнглийский
Страницы (с-по)89-92
Число страниц4
ЖурналJurnal Teknologi
Том78
Номер выпуска5-6
DOI
СостояниеОпубликовано - 1 янв 2016

ASJC Scopus subject areas

  • Engineering(all)

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