In vivo quantification of transvascular water exchange during the acute phase of permanent stroke

Young R. Kim, E. Tejima, S. Huang, D. N. Atochin, G. Dai, E. H. Lo, P. L. Huang, A. Bogdanov, B. R. Rosen

Результат исследований: Материалы для журналаСтатья

20 Цитирования (Scopus)

Выдержка

Mechanisms that underlie early ischemic damages to the blood-brain-barrier (BBB) are not well understood. This study presents a novel magnetic resonance imaging (MRI) technique using a widely available pulse sequence and a long-circulating intravascular contrast agent to quantify water movements across the BBB at early stages of stroke progression. We characterized the integrity of the BBB by measuring the flip angle dependence of the water exchange-affected MRI signal intensity, to generate an efficient quantitative index of vascular permeability (WEI, or water exchange index). We performed in vivo MRI experiments to measure the transvascular WEI immediately after the permanent filament occlusion of the middle cerebral artery of mice (n = 5), in which we monitored changes in blood volume (Vb), apparent diffusion coefficient (ADC), and intra-/extravascular WEI for 4 hours. Statistically significant elevations (P <0.05) of WEI in the ischemic tissue were observed as early as 1 hour after ischemic onset. Initial reduction of the apparent blood volume (Vapp) in the infarct cortex was followed by a continuous increase of Vapp over time. Although the measured ADC in the ipsilesional cortex continuously decreased, the abnormally high intra-/extravascular WEI remained constant at a significantly elevated level, indicating apparent BBB injury at this early stage of stroke.

Язык оригиналаАнглийский
Страницы (с-по)813-821
Число страниц9
ЖурналMagnetic Resonance in Medicine
Том60
Номер выпуска4
DOI
СостояниеОпубликовано - окт 2008
Опубликовано для внешнего пользованияДа

Отпечаток

Stroke
Blood-Brain Barrier
Water
Magnetic Resonance Imaging
Blood Volume
Water Movements
Middle Cerebral Artery Infarction
Capillary Permeability
Brain Injuries
Contrast Media

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Цитировать

In vivo quantification of transvascular water exchange during the acute phase of permanent stroke. / Kim, Young R.; Tejima, E.; Huang, S.; Atochin, D. N.; Dai, G.; Lo, E. H.; Huang, P. L.; Bogdanov, A.; Rosen, B. R.

В: Magnetic Resonance in Medicine, Том 60, № 4, 10.2008, стр. 813-821.

Результат исследований: Материалы для журналаСтатья

Kim, Young R. ; Tejima, E. ; Huang, S. ; Atochin, D. N. ; Dai, G. ; Lo, E. H. ; Huang, P. L. ; Bogdanov, A. ; Rosen, B. R. / In vivo quantification of transvascular water exchange during the acute phase of permanent stroke. В: Magnetic Resonance in Medicine. 2008 ; Том 60, № 4. стр. 813-821.
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