In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Elina A. Genina, Yulia I. Svenskaya, Irina Yu Yanina, Leonid E. Dolotov, Nikita A. Navolokin, Alexey N. Bashkatov, Georgy S. Terentyuk, Alla B. Bucharskaya, Galina N. Maslyakova, Dmitry A. Gorin, Valery V. Tuchin, Gleb B. Sukhorukov

Результат исследований: Материалы для журналаСтатья

16 Цитирования (Scopus)

Выдержка

We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 µm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.

Язык оригиналаАнглийский
Страницы (с-по)2082-2087
Число страниц6
ЖурналBiomedical Optics Express
Том7
Номер выпуска6
DOI
СостояниеОпубликовано - 1 июн 2016
Опубликовано для внешнего пользованияДа

Отпечаток

Calcium Carbonate
calcium carbonates
Dermis
Nanoparticles
delivery
Lasers
Solid-State Lasers
Optical Coherence Tomography
nanoparticles
Skin
rats
lasers
YAG lasers
pulsed lasers
dissolving
tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Цитировать

Genina, E. A., Svenskaya, Y. I., Yanina, I. Y., Dolotov, L. E., Navolokin, N. A., Bashkatov, A. N., ... Sukhorukov, G. B. (2016). In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. Biomedical Optics Express, 7(6), 2082-2087. https://doi.org/10.1364/BOE.7.002082

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. / Genina, Elina A.; Svenskaya, Yulia I.; Yanina, Irina Yu; Dolotov, Leonid E.; Navolokin, Nikita A.; Bashkatov, Alexey N.; Terentyuk, Georgy S.; Bucharskaya, Alla B.; Maslyakova, Galina N.; Gorin, Dmitry A.; Tuchin, Valery V.; Sukhorukov, Gleb B.

В: Biomedical Optics Express, Том 7, № 6, 01.06.2016, стр. 2082-2087.

Результат исследований: Материалы для журналаСтатья

Genina, EA, Svenskaya, YI, Yanina, IY, Dolotov, LE, Navolokin, NA, Bashkatov, AN, Terentyuk, GS, Bucharskaya, AB, Maslyakova, GN, Gorin, DA, Tuchin, VV & Sukhorukov, GB 2016, 'In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers', Biomedical Optics Express, том. 7, № 6, стр. 2082-2087. https://doi.org/10.1364/BOE.7.002082
Genina EA, Svenskaya YI, Yanina IY, Dolotov LE, Navolokin NA, Bashkatov AN и соавт. In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. Biomedical Optics Express. 2016 Июнь 1;7(6):2082-2087. https://doi.org/10.1364/BOE.7.002082
Genina, Elina A. ; Svenskaya, Yulia I. ; Yanina, Irina Yu ; Dolotov, Leonid E. ; Navolokin, Nikita A. ; Bashkatov, Alexey N. ; Terentyuk, Georgy S. ; Bucharskaya, Alla B. ; Maslyakova, Galina N. ; Gorin, Dmitry A. ; Tuchin, Valery V. ; Sukhorukov, Gleb B. / In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. В: Biomedical Optics Express. 2016 ; Том 7, № 6. стр. 2082-2087.
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AU - Navolokin, Nikita A.

AU - Bashkatov, Alexey N.

AU - Terentyuk, Georgy S.

AU - Bucharskaya, Alla B.

AU - Maslyakova, Galina N.

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