In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

Elina A. Genina, Yulia I. Svenskaya, Irina Yu Yanina, Leonid E. Dolotov, Nikita A. Navolokin, Alexey N. Bashkatov, Georgy S. Terentyuk, Alla B. Bucharskaya, Galina N. Maslyakova, Dmitry A. Gorin, Valery V. Tuchin, Gleb B. Sukhorukov

Результат исследований: Материалы для журналаСтатья

17 Цитирования (Scopus)

Аннотация

We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 µm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.

Язык оригиналаАнглийский
Страницы (с-по)2082-2087
Число страниц6
ЖурналBiomedical Optics Express
Том7
Номер выпуска6
DOI
СостояниеОпубликовано - 1 июн 2016
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

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  • Цитировать

    Genina, E. A., Svenskaya, Y. I., Yanina, I. Y., Dolotov, L. E., Navolokin, N. A., Bashkatov, A. N., Terentyuk, G. S., Bucharskaya, A. B., Maslyakova, G. N., Gorin, D. A., Tuchin, V. V., & Sukhorukov, G. B. (2016). In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers. Biomedical Optics Express, 7(6), 2082-2087. https://doi.org/10.1364/BOE.7.002082