Implantation of track-etched membranes covered by prenatal stromal cells for experimental bullous keratopathy treatment

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Аннотация

A study on the use of track etched membranes (TM) based on the polyethylene terephthalate (PET), including those modified with cold plasma, followed by layering of prenatal stromal cell (PSC) culture on the material surface in vitro in the surgical treatment of a bullous keratopathy (BK) of the cornea has been conducted. The study was conducted on 16 Sylvilagus bachmani rabbits, which after BK modelling were divided into 4 groups: the 1st group was a control group of 4 animals (4 eyes); the 2nd group was a group of 4 animals (4 eyes) which were implanted by TM; the 3rd group was a group of 4 animals (4 eyes) which were implanted by TM with cells; the 4th group was a group of 4 animals (4 eyes) which were implanted by plasma modified TM with cells. TM was obtained by irradiating PET with 40Ar+8 ions and subsequent chemical etching. Eyes were enucleated for histological examination after 8 weeks from the start of the experiment. As a result of the research, it was found that the implantation of TM with a preliminary layering of human PSC promotes the growth of the fibroblast population in the cornea stroma and forming of the leukocyte (lymphocytic and eosinophilic-basophilic) infiltration compared with the implantation of TM without a cellular component. In addition the implantation of TM contributes to a twofold decrease in the induced by BK cornea edema.

Язык оригиналаАнглийский
Название основной публикацииProceedings of the International Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2019
РедакторыVictor E. Panin, Sergey G. Psakhie, Vasily M. Fomin
ИздательAmerican Institute of Physics Inc.
ISBN (электронное издание)9780735419124
DOI
СостояниеОпубликовано - 19 ноя 2019
СобытиеInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2019 - Tomsk, Российская Федерация
Продолжительность: 1 окт 20195 окт 2019

Серия публикаций

НазваниеAIP Conference Proceedings
Том2167
ISSN (печатное издание)0094-243X
ISSN (электронное издание)1551-7616

Конференция

КонференцияInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2019
СтранаРоссийская Федерация
ГородTomsk
Период1.10.195.10.19

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Fingerprint Подробные сведения о темах исследования «Implantation of track-etched membranes covered by prenatal stromal cells for experimental bullous keratopathy treatment». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать

    Filippova, E. O., Pichugin, V. F., & Khlusov, I. A. (2019). Implantation of track-etched membranes covered by prenatal stromal cells for experimental bullous keratopathy treatment. В V. E. Panin, S. G. Psakhie, & V. M. Fomin (Ред.), Proceedings of the International Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2019 [020105] (AIP Conference Proceedings; Том 2167). American Institute of Physics Inc.. https://doi.org/10.1063/1.5131972