Gipoksicheskie bioreduktivnye agenty: vozmozhnye immunnye i retseptoroposredovannye mekhanizmy protivoopukholevogo deistviia.

Результат исследований: Материалы для журналаОбзорная статья

1 цитирование (Scopus)

Выдержка

The article discusses the possible mechanisms of the antineoplastic effect of hypoxic bioreducing agents (HBA) when they are used in low nonhypoxic doses. Experimental and clinical studies provide evidence of the occurrence of stages which in administration of HBA into the organisms of the tumor-carrier may develop in succession, leading to stimulation of antineoplastic immunity: GBA activation in the hypoxic neoplastic tissue, conjugation of HBA metabolites with the macromolecules of the tumor cells, and presentation of the epitopes of neoantigens in association with the main complex of class I histocompatibility (MCH) cytolysis of these cells by T-killers. This process may be similar to that in contact sensitivity to low-molecular compounds (a variant of the reaction of delayed hypersensitivity [DH]) in the neoplastic focus. It is suggested that direct control of the effect of HBA on the immunocompetent and/or tumor cells may occur additively to or synergically with this process as the result of interaction of these compounds with the surface or intracellular receptors. It cannot be excluded that the activated HBA may force the endogenic ligands out of the nucleophilic centers of these receptors and realize receptor-mediated control of gene expression.

Язык оригиналаРусский
Страницы (с-по)67-74
Число страниц8
ЖурналEksperimental'naia i klinicheskaia farmakologiia
Том62
Номер выпуска3
СостояниеОпубликовано - мая 1999
Опубликовано для внешнего пользованияДа

Отпечаток

Antineoplastic Agents
Tumors
Neoplasms
Histocompatibility
Contact Dermatitis
Delayed Hypersensitivity
Cells
Epitopes
Immunity
Ligands
Gene Expression
Metabolites
Macromolecules
Gene expression
Chemical activation
Association reactions
Tissue
Clinical Studies

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Цитировать

Gipoksicheskie bioreduktivnye agenty : vozmozhnye immunnye i retseptoroposredovannye mekhanizmy protivoopukholevogo deistviia. / Shchepetkin, I. A.

В: Eksperimental'naia i klinicheskaia farmakologiia, Том 62, № 3, 05.1999, стр. 67-74.

Результат исследований: Материалы для журналаОбзорная статья

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abstract = "The article discusses the possible mechanisms of the antineoplastic effect of hypoxic bioreducing agents (HBA) when they are used in low nonhypoxic doses. Experimental and clinical studies provide evidence of the occurrence of stages which in administration of HBA into the organisms of the tumor-carrier may develop in succession, leading to stimulation of antineoplastic immunity: GBA activation in the hypoxic neoplastic tissue, conjugation of HBA metabolites with the macromolecules of the tumor cells, and presentation of the epitopes of neoantigens in association with the main complex of class I histocompatibility (MCH) cytolysis of these cells by T-killers. This process may be similar to that in contact sensitivity to low-molecular compounds (a variant of the reaction of delayed hypersensitivity [DH]) in the neoplastic focus. It is suggested that direct control of the effect of HBA on the immunocompetent and/or tumor cells may occur additively to or synergically with this process as the result of interaction of these compounds with the surface or intracellular receptors. It cannot be excluded that the activated HBA may force the endogenic ligands out of the nucleophilic centers of these receptors and realize receptor-mediated control of gene expression.",
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