Hypoiodite-mediated cyclopropanation of alkenes

Akira Yoshimura, Steven R. Koski, Brent J. Kastern, Jonathan M. Fuchs, T. Nicholas Jones, Roza Y. Yusubova, Victor N. Nemykin, Viktor Vladimirovich Zhdankin

Результат исследований: Материалы для журналаСтатья

9 Цитирования (Scopus)

Выдержка

An efficient, transition metal-free procedure for the cyclopropanation of alkenes using malononitrile and the LiI-tBuOCl combination under mild reaction conditions is described. The reaction mechanism most likely involves tBuOI generated in situ from LiI and tBuOCl. The utility of this new methodology has been demonstrated by the synthesis of a potential HIV-1 RT inhibitor.

Язык оригиналаАнглийский
Страницы (с-по)5895-5898
Число страниц4
ЖурналChemistry (Weinheim an der Bergstrasse, Germany)
Том20
Номер выпуска20
DOI
СостояниеОпубликовано - 12 мая 2014

Отпечаток

Alkenes
Olefins
Transition metals
HIV-1
Metals
dicyanmethane
hypoiodous acid

ASJC Scopus subject areas

  • Medicine(all)

Цитировать

Hypoiodite-mediated cyclopropanation of alkenes. / Yoshimura, Akira; Koski, Steven R.; Kastern, Brent J.; Fuchs, Jonathan M.; Jones, T. Nicholas; Yusubova, Roza Y.; Nemykin, Victor N.; Zhdankin, Viktor Vladimirovich.

В: Chemistry (Weinheim an der Bergstrasse, Germany), Том 20, № 20, 12.05.2014, стр. 5895-5898.

Результат исследований: Материалы для журналаСтатья

Yoshimura, Akira ; Koski, Steven R. ; Kastern, Brent J. ; Fuchs, Jonathan M. ; Jones, T. Nicholas ; Yusubova, Roza Y. ; Nemykin, Victor N. ; Zhdankin, Viktor Vladimirovich. / Hypoiodite-mediated cyclopropanation of alkenes. В: Chemistry (Weinheim an der Bergstrasse, Germany). 2014 ; Том 20, № 20. стр. 5895-5898.
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abstract = "An efficient, transition metal-free procedure for the cyclopropanation of alkenes using malononitrile and the LiI-tBuOCl combination under mild reaction conditions is described. The reaction mechanism most likely involves tBuOI generated in situ from LiI and tBuOCl. The utility of this new methodology has been demonstrated by the synthesis of a potential HIV-1 RT inhibitor.",
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author = "Akira Yoshimura and Koski, {Steven R.} and Kastern, {Brent J.} and Fuchs, {Jonathan M.} and Jones, {T. Nicholas} and Yusubova, {Roza Y.} and Nemykin, {Victor N.} and Zhdankin, {Viktor Vladimirovich}",
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T1 - Hypoiodite-mediated cyclopropanation of alkenes

AU - Yoshimura, Akira

AU - Koski, Steven R.

AU - Kastern, Brent J.

AU - Fuchs, Jonathan M.

AU - Jones, T. Nicholas

AU - Yusubova, Roza Y.

AU - Nemykin, Victor N.

AU - Zhdankin, Viktor Vladimirovich

PY - 2014/5/12

Y1 - 2014/5/12

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AB - An efficient, transition metal-free procedure for the cyclopropanation of alkenes using malononitrile and the LiI-tBuOCl combination under mild reaction conditions is described. The reaction mechanism most likely involves tBuOI generated in situ from LiI and tBuOCl. The utility of this new methodology has been demonstrated by the synthesis of a potential HIV-1 RT inhibitor.

KW - cyclopropanation reactions

KW - hypoiodous acid

KW - iodine

KW - oxidation

KW - small ring systems

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