Hypervalent Iodine(III) Reagent Mediated Regioselective Cycloaddition of Aldoximes with Enaminones

Akira Yoshimura, Melissa E. Jarvi, Michael T. Shea, Cody L. Makitalo, Gregory T. Rohde, Mekhman S. Yusubov, Akio Saito, Viktor V. Zhdankin

Результат исследований: Материалы для журналаСтатья

1 Цитирования (Scopus)

Аннотация

An efficient oxidative cycloaddition of enaminones with nitrile oxides generated in situ from respective aldoximes using hypervalent iodine reagents has been developed. Reactions of various aldoximes with enaminones in the presence of [hydroxy(tosyloxy)iodo]benzene involved the regioselective cycloaddition reaction resulting in the formation of the 3,4-disubstituted isoxazoles in moderate to good yields. Structures of several isoxazole products were confirmed by a single X-ray crystallography.

Язык оригиналаАнглийский
Страницы (с-по)6682-6689
Число страниц8
ЖурналEuropean Journal of Organic Chemistry
Том2019
Номер выпуска39
DOI
СостояниеОпубликовано - 24 окт 2019

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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