Hypervalent Iodine Reagent Mediated Oxidative Heterocyclization of Aldoximes with Heterocyclic Alkenes

Результат исследований: Материалы для журналаСтатья

8 Цитирования (Scopus)

Аннотация

An efficient cycloaddition of heterocyclic alkenes with nitrile oxides generated in situ from the corresponding aldoximes using organohypervalent iodine(III) reagent, [hydroxy(tosyloxy)iodo]benzene (Koser's reagent), has been developed. The oxidative cyclization of various aldoximes with 1-propene-1,3-sultone affords the respective isoxazoline-ring-fused heterobicyclic products in moderate to good yields. Furthermore, the reaction of aldoxime with a cyclic phospholene-oxide under similar conditions produces the corresponding heterobicyclic phospholene oxides in moderate yields. The structures of bicyclic phospholene oxide and two sultones were established by single-crystal X-ray crystallography.

Язык оригиналаАнглийский
Страницы (с-по)11742-11751
Число страниц10
ЖурналJournal of Organic Chemistry
Том82
Номер выпуска22
DOI
СостояниеОпубликовано - 17 ноя 2017

ASJC Scopus subject areas

  • Organic Chemistry

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