Выдержка
Background and aims: Hypercholesterolemia may increase stroke risk by accelerating atherosclerosis and narrowing luminal diameter in cerebral vessels as well as disrupting vascular endothelial and smooth muscle function. We tested the hypothesis that that hypercholesterolemia impairs cerebrovascular function and worsens cerebral blood flow (CBF) deficit and tissue outcome after focal ischemia even in the absence of hemodynamically significant vessel narrowing. Methods: We tested this hypothesis in ApoE knockout (KO) mice using high spatiotemporal resolution laser speckle flowmetry through intact skull noninvasively, and studied the hemodynamic impact of hypercholesterolemia on the evolution of CBF deficit in focal cerebral ischemia. Wild type (WT, C57BL/6), ApoE KO or ApoE/eNOS double KO mice were fed high-fat quot;westernquot; diet for 4, 8, or 10 weeks starting at 4 weeks of age. Histopathological examination of extracranial arteries in 14 week-old ApoE KO showed only minimal atherosclerotic changes such as fatty streaks with subendothelial foam cells. Intracranial arteries did not develop atherosclerotic lesions even after 12 months, despite severe extracranial atherosclerosis. Results: Mean arterial blood pressure was higher in ApoE KO compared to WT in all age groups (94+/-2 vs. 85+/-2 mmHg, respectively; n=17 each, p
| Язык оригинала | Английский |
|---|---|
| Журнал | Journal of Cerebral Blood Flow and Metabolism |
| Том | 27 |
| Номер выпуска | SUPPL. 1 |
| Состояние | Опубликовано - 13 ноя 2007 |
| Опубликовано для внешнего пользования | Да |
Отпечаток
ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
- Endocrinology, Diabetes and Metabolism
Цитировать
Hypercholesterolemia worsens the blood flow deficit in focal cerebral ischemia in the absence of atherosclerosis. / Hwa, Kyoung Shin; Li, James A Lapointe; Atochin, Dmitriy N.; Moskowitz, Michael A.; Huang, Paul L.; Ayata, Cenk.
В: Journal of Cerebral Blood Flow and Metabolism, Том 27, № SUPPL. 1, 13.11.2007.Результат исследований: Материалы для журнала › Статья
}
TY - JOUR
T1 - Hypercholesterolemia worsens the blood flow deficit in focal cerebral ischemia in the absence of atherosclerosis
AU - Hwa, Kyoung Shin
AU - Li, James A Lapointe
AU - Atochin, Dmitriy N.
AU - Moskowitz, Michael A.
AU - Huang, Paul L.
AU - Ayata, Cenk
PY - 2007/11/13
Y1 - 2007/11/13
N2 - Background and aims: Hypercholesterolemia may increase stroke risk by accelerating atherosclerosis and narrowing luminal diameter in cerebral vessels as well as disrupting vascular endothelial and smooth muscle function. We tested the hypothesis that that hypercholesterolemia impairs cerebrovascular function and worsens cerebral blood flow (CBF) deficit and tissue outcome after focal ischemia even in the absence of hemodynamically significant vessel narrowing. Methods: We tested this hypothesis in ApoE knockout (KO) mice using high spatiotemporal resolution laser speckle flowmetry through intact skull noninvasively, and studied the hemodynamic impact of hypercholesterolemia on the evolution of CBF deficit in focal cerebral ischemia. Wild type (WT, C57BL/6), ApoE KO or ApoE/eNOS double KO mice were fed high-fat quot;westernquot; diet for 4, 8, or 10 weeks starting at 4 weeks of age. Histopathological examination of extracranial arteries in 14 week-old ApoE KO showed only minimal atherosclerotic changes such as fatty streaks with subendothelial foam cells. Intracranial arteries did not develop atherosclerotic lesions even after 12 months, despite severe extracranial atherosclerosis. Results: Mean arterial blood pressure was higher in ApoE KO compared to WT in all age groups (94+/-2 vs. 85+/-2 mmHg, respectively; n=17 each, p
AB - Background and aims: Hypercholesterolemia may increase stroke risk by accelerating atherosclerosis and narrowing luminal diameter in cerebral vessels as well as disrupting vascular endothelial and smooth muscle function. We tested the hypothesis that that hypercholesterolemia impairs cerebrovascular function and worsens cerebral blood flow (CBF) deficit and tissue outcome after focal ischemia even in the absence of hemodynamically significant vessel narrowing. Methods: We tested this hypothesis in ApoE knockout (KO) mice using high spatiotemporal resolution laser speckle flowmetry through intact skull noninvasively, and studied the hemodynamic impact of hypercholesterolemia on the evolution of CBF deficit in focal cerebral ischemia. Wild type (WT, C57BL/6), ApoE KO or ApoE/eNOS double KO mice were fed high-fat quot;westernquot; diet for 4, 8, or 10 weeks starting at 4 weeks of age. Histopathological examination of extracranial arteries in 14 week-old ApoE KO showed only minimal atherosclerotic changes such as fatty streaks with subendothelial foam cells. Intracranial arteries did not develop atherosclerotic lesions even after 12 months, despite severe extracranial atherosclerosis. Results: Mean arterial blood pressure was higher in ApoE KO compared to WT in all age groups (94+/-2 vs. 85+/-2 mmHg, respectively; n=17 each, p
UR - http://www.scopus.com/inward/record.url?scp=36348989551&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36348989551&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:36348989551
VL - 27
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - SUPPL. 1
ER -