Hydrolytic Stability of Aqueous Solutions of Salicin

S. V. Nekhoroshev, A. V. Nekhorosheva, A. B. Sabutova, E. Kh Botirov, A. A. Drenin, G. B. Slepchenko, N. V. Gornikov

Результат исследований: Материалы для журналаСтатьярецензирование

Аннотация

The kinetics of salicin acid hydrolysis in aqueous solutions were studied. The salicin content in the reaction mixtures was determined by HPLC with UV detection. The salicin hydrolysis rate depended more on the solution acidity than on the temperature. The dependences of the salicin hydrolysis rate constant on temperature and solution acidity were established. Salicin was most reactive in aqueous solutions at 90°C and pH < 1.0. Salicin preparations could be stored for more than one year without noticeable decomposition at room temperature and pH > 2.0

Язык оригиналаАнглийский
Страницы (с-по)857-860
Число страниц4
ЖурналPharmaceutical Chemistry Journal
Том54
Номер выпуска8
DOI
СостояниеОпубликовано - ноя 2020

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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