Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia

Evgeny A. Ermakov, Svetlana A. Ivanova, Valentina N. Buneva, Georgy A. Nevinsky

Результат исследований: Материалы для журналаСтатьярецензирование

6 Цитирования (Scopus)

Аннотация

Significant importance of autoimmune changes in the pathogenesis of schizophrenia (SCZ) is not established. Here, we present the first evidence that autoantibodies of 100% SCZ patients possess RNase activity: сCMP > poly(C) > poly(A) > yeast RNA. In addition, we have got an unexpected result: there was revealed site-specific hydrolysis of four known SCZ specific microRNAs (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p) playing an important role in the regulation of several genes functioning. Three major of cleavage sites are located in the microRNA loops or duplex parts directly articulated with the loops. RNase abzymes can contribute to decreasing of microRNAs effects on the functioning of numerous genes and the products of their transcription. Therefore, abzymes with RNase activity may be to some extent important for the development of schizophrenia.

Язык оригиналаАнглийский
Страницы (с-по)153-164
Число страниц12
ЖурналIUBMB Life
Том70
Номер выпуска2
DOI
СостояниеОпубликовано - 1 фев 2018
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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