Halonal is a phenobarbital inductor of the monooxygenase system

A. S. Saratikov, T. P. Novozheeva, R. R. Akhmedzhanov

Результат исследований: Материалы для журналаСтатья

1 Цитирования (Scopus)

Аннотация

Experiments on rats demonstrated induction of the hepatic monooxygenase system with halonal. The effects of halonal and phenobarbital on the contents of cytochrome P-450 and its isoform P-450b+e and on the rate of substrate metabolism were similar. This suggests that enzyme-inducing activity of halonal is determined by the effect of its major metabolite. It cannot be excluded that halonal molecules possess intrinsic enzyme-inducing activity.

Язык оригиналаАнглийский
Страницы (с-по)264-266
Число страниц3
ЖурналBulletin of Experimental Biology and Medicine
Том134
Номер выпуска3
DOI
СостояниеОпубликовано - 1 сен 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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