Functional state of myocardial mitochondria in ischemia reperfusion of the heart in rats adapted to hypoxia

Yu B. Lishmanov, N. V. Naryzhnaya, L. N. Maslov, E. S. Prokudina, A. S. Gorbunov, S. Yu Tsibulnikov

Результат исследований: Материалы для журналаСтатья

3 Цитирования (Scopus)

Выдержка

Parameters of respiration, transmembrane potential, and Ca 2+-binding capacity of mitochondria isolated from Langendorff-perfused hearts of rats adapted to normobaric hypoxia were analyzed. Ischemia and reperfusion modeling in intact and adapted animals reduced Ca 2+-binding capacity of mitochondria, which indicated increased sensitivity of mitochondrial permeability transition pores (MPTP) to calcium ions. These changes were accompanied by a decrease in transmembrane potential, ADP/O coeffi cient (ratio of added ADP to oxygen consumption in State 3), and inhibition of State 3 respiration. At the same time, adaptation attenuated the negative effect of ischemia and reperfusion on the functional state of mitochondria.

Язык оригиналаАнглийский
Страницы (с-по)645-648
Число страниц4
ЖурналBulletin of Experimental Biology and Medicine
Том156
Номер выпуска5
DOI
СостояниеОпубликовано - 1 янв 2014

Отпечаток

Heart Mitochondria
Mitochondria
Reperfusion
Rats
Ischemia
Membrane Potentials
Adenosine Diphosphate
Respiration
Oxygen Consumption
Animals
Ions
Oxygen
Calcium
Hypoxia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Цитировать

Functional state of myocardial mitochondria in ischemia reperfusion of the heart in rats adapted to hypoxia. / Lishmanov, Yu B.; Naryzhnaya, N. V.; Maslov, L. N.; Prokudina, E. S.; Gorbunov, A. S.; Tsibulnikov, S. Yu.

В: Bulletin of Experimental Biology and Medicine, Том 156, № 5, 01.01.2014, стр. 645-648.

Результат исследований: Материалы для журналаСтатья

Lishmanov, Yu B. ; Naryzhnaya, N. V. ; Maslov, L. N. ; Prokudina, E. S. ; Gorbunov, A. S. ; Tsibulnikov, S. Yu. / Functional state of myocardial mitochondria in ischemia reperfusion of the heart in rats adapted to hypoxia. В: Bulletin of Experimental Biology and Medicine. 2014 ; Том 156, № 5. стр. 645-648.
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T1 - Functional state of myocardial mitochondria in ischemia reperfusion of the heart in rats adapted to hypoxia

AU - Lishmanov, Yu B.

AU - Naryzhnaya, N. V.

AU - Maslov, L. N.

AU - Prokudina, E. S.

AU - Gorbunov, A. S.

AU - Tsibulnikov, S. Yu

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AB - Parameters of respiration, transmembrane potential, and Ca 2+-binding capacity of mitochondria isolated from Langendorff-perfused hearts of rats adapted to normobaric hypoxia were analyzed. Ischemia and reperfusion modeling in intact and adapted animals reduced Ca 2+-binding capacity of mitochondria, which indicated increased sensitivity of mitochondrial permeability transition pores (MPTP) to calcium ions. These changes were accompanied by a decrease in transmembrane potential, ADP/O coeffi cient (ratio of added ADP to oxygen consumption in State 3), and inhibition of State 3 respiration. At the same time, adaptation attenuated the negative effect of ischemia and reperfusion on the functional state of mitochondria.

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