Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer

E. I. Shramova, G. M. Proshkina, S. P. Chumakov, Yu M. Khodarovich, S. M. Deyev

Результат исследований: Материалы для журналаСтатья

12 Цитирования (Scopus)

Аннотация

In this study, we investigated the possibility of phototoxic flavoprotein miniSOG (photosensitizer) excitation in cancer cells by bioluminescence occurring when luciferase NanoLuc oxidizes its substrate, furimazine. We have shown that the phototoxic flavoprotein miniSOG expressed in eukaryotic cells in fusion with NanoLuc luciferase is activated in the presence of its substrate, furimazine. Upon such condition, miniSOG possesses photoinduced cytotoxicity and causes a 48% cell death level in a stably transfected cell line.

Язык оригиналаАнглийский
Страницы (с-по)118-125
Число страниц8
ЖурналActa Naturae
Том8
Номер выпуска4
СостояниеОпубликовано - 2016

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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  • Цитировать

    Shramova, E. I., Proshkina, G. M., Chumakov, S. P., Khodarovich, Y. M., & Deyev, S. M. (2016). Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer. Acta Naturae, 8(4), 118-125.