Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment

Georgy Mikhaylov, Ursa Mikac, Anna A. Magaeva, Volya I. Itin, Evgeniy P. Naiden, Ivan Psakhye, Liane Babes, Thomas Reinheckel, Christoph Peters, Robert Zeiser, Matthew Bogyo, Vito Turk, Sergey G. Psakhye, Boris Turk, Olga Vasiljeva

Результат исследований: Материалы для журналаСтатья

264 Цитирования (Scopus)

Выдержка

The tumour microenvironment regulates tumour progression and the spread of cancer in the body. Targeting the stromal cells that surround cancer cells could, therefore, improve the effectiveness of existing cancer treatments. Here, we show that magnetic nanoparticle clusters encapsulated inside a liposome can, under the influence of an external magnet, target both the tumour and its microenvironment. We use the outstanding T 2 contrast properties (r 2 = 573-1,286s -1 mM -1) of these ferri-liposomes, which are ∼95nm in diameter, to non-invasively monitor drug delivery in vivo. We also visualize the targeting of the tumour microenvironment by the drug-loaded ferri-liposomes and the uptake of a model probe by cells. Furthermore, we used the ferri-liposomes to deliver a cathepsin protease inhibitor to a mammary tumour and its microenvironment in a mouse, which substantially reduced the size of the tumour compared with systemic delivery of the same drug.

Язык оригиналаАнглийский
Страницы (с-по)594-602
Число страниц9
ЖурналNature Nanotechnology
Том6
Номер выпуска9
DOI
СостояниеОпубликовано - сен 2011

Отпечаток

Liposomes
Magnetic resonance imaging
Tumors
delivery
drugs
tumors
cancer
Cathepsins
protease
Oncology
Protease Inhibitors
Drug delivery
progressions
Pharmaceutical Preparations
inhibitors
Magnets
mice
Drug Delivery Systems
monitors
magnets

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

Цитировать

Mikhaylov, G., Mikac, U., Magaeva, A. A., Itin, V. I., Naiden, E. P., Psakhye, I., ... Vasiljeva, O. (2011). Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nature Nanotechnology, 6(9), 594-602. https://doi.org/10.1038/nnano.2011.112

Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. / Mikhaylov, Georgy; Mikac, Ursa; Magaeva, Anna A.; Itin, Volya I.; Naiden, Evgeniy P.; Psakhye, Ivan; Babes, Liane; Reinheckel, Thomas; Peters, Christoph; Zeiser, Robert; Bogyo, Matthew; Turk, Vito; Psakhye, Sergey G.; Turk, Boris; Vasiljeva, Olga.

В: Nature Nanotechnology, Том 6, № 9, 09.2011, стр. 594-602.

Результат исследований: Материалы для журналаСтатья

Mikhaylov, G, Mikac, U, Magaeva, AA, Itin, VI, Naiden, EP, Psakhye, I, Babes, L, Reinheckel, T, Peters, C, Zeiser, R, Bogyo, M, Turk, V, Psakhye, SG, Turk, B & Vasiljeva, O 2011, 'Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment', Nature Nanotechnology, том. 6, № 9, стр. 594-602. https://doi.org/10.1038/nnano.2011.112
Mikhaylov G, Mikac U, Magaeva AA, Itin VI, Naiden EP, Psakhye I и соавт. Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nature Nanotechnology. 2011 Сент.;6(9):594-602. https://doi.org/10.1038/nnano.2011.112
Mikhaylov, Georgy ; Mikac, Ursa ; Magaeva, Anna A. ; Itin, Volya I. ; Naiden, Evgeniy P. ; Psakhye, Ivan ; Babes, Liane ; Reinheckel, Thomas ; Peters, Christoph ; Zeiser, Robert ; Bogyo, Matthew ; Turk, Vito ; Psakhye, Sergey G. ; Turk, Boris ; Vasiljeva, Olga. / Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. В: Nature Nanotechnology. 2011 ; Том 6, № 9. стр. 594-602.
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