Аннотация
We have created novel HER2-overexpressing human ovarian adenocarcinoma cell line stably transfected with far-red fluorescent protein TurboFP635. Growth characteristics, adhesion capacity and morphology of the cells do not differ from that of parental cell line. The obtained cell line (SKOV-kat) was confirmed to have high level of expression of the tumor marker HER2 comparable to that of initial cell line SKOV-3. The SKOV-kat cell line is designed for further establishment of experimental fluorescent models of HER2-overexpressing human ovarian cancer that make it possible to optimize and reduce the cost of preclinical study of agents for treatment of this disease.
| Язык оригинала | Английский |
|---|---|
| Страницы (с-по) | 410-412 |
| Число страниц | 3 |
| Журнал | Doklady Biochemistry and Biophysics |
| Том | 465 |
| Номер выпуска | 1 |
| DOI | |
| Состояние | Опубликовано - 1 ноя 2015 |
| Опубликовано для внешнего пользования | Да |
ASJC Scopus subject areas
- Biophysics
- Chemistry(all)
- Medicine(all)
- Biochemistry
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Цитировать
Balalaeva, I. V., Sokolova, E. A., Brilkina, A. A., Deyev, S. M., & Petrov, R. V. (2015). Far-red fluorescent cell line for preclinical study of HER2-targeted agents. Doklady Biochemistry and Biophysics, 465(1), 410-412. https://doi.org/10.1134/S1607672915060174