Far-red fluorescent cell line for preclinical study of HER2-targeted agents

Аннотация

We have created novel HER2-overexpressing human ovarian adenocarcinoma cell line stably transfected with far-red fluorescent protein TurboFP635. Growth characteristics, adhesion capacity and morphology of the cells do not differ from that of parental cell line. The obtained cell line (SKOV-kat) was confirmed to have high level of expression of the tumor marker HER2 comparable to that of initial cell line SKOV-3. The SKOV-kat cell line is designed for further establishment of experimental fluorescent models of HER2-overexpressing human ovarian cancer that make it possible to optimize and reduce the cost of preclinical study of agents for treatment of this disease.

Язык оригинала	Английский
Страницы (с-по)	410-412
Число страниц	3
Журнал	Doklady Biochemistry and Biophysics
Том	465
Номер выпуска	1
DOI	https://doi.org/10.1134/S1607672915060174
Состояние	Опубликовано - 1 ноя 2015
Опубликовано для внешнего пользования	Да

ASJC Scopus subject areas

Biophysics
Chemistry(all)
Medicine(all)
Biochemistry

Доступ к документу

10.1134/S1607672915060174

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Цитировать

Far-red fluorescent cell line for preclinical study of HER2-targeted agents. / Balalaeva, I. V.; Sokolova, E. A.; Brilkina, A. A.; Deyev, S. M.; Petrov, R. V.

В: Doklady Biochemistry and Biophysics, Том 465, № 1, 01.11.2015, стр. 410-412.

Результат исследований: Материалы для журнала › Статья › рецензирование

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AU - Balalaeva, I. V.

AU - Sokolova, E. A.

AU - Brilkina, A. A.

AU - Deyev, S. M.

AU - Petrov, R. V.

PY - 2015/11/1

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