Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard

B. Lishmanov Yu., V. I. Chernov, N. G. Krivonogov, A. O. Malysheva, V. Vesnina Zh., T. Rebrova Yu., I. Shvera Yu.

Результат исследований: Материалы для журналаСтатья

Выдержка

Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of 199Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.

Язык оригиналаАнглийский
Страницы (с-по)6-9
Число страниц4
ЖурналMeditsinskaya Radiologiya i Radiatsionnaya Bezopasnost
Том40
Номер выпуска2
СостояниеОпубликовано - 1995

Отпечаток

Pharmacokinetics
Rats
Animals
Blood
Imaging techniques

ASJC Scopus subject areas

  • Nuclear Energy and Engineering

Цитировать

Lishmanov Yu., B., Chernov, V. I., Krivonogov, N. G., Malysheva, A. O., Vesnina Zh., V., Rebrova Yu., T., & Shvera Yu., I. (1995). Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost, 40(2), 6-9.

Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard. / Lishmanov Yu., B.; Chernov, V. I.; Krivonogov, N. G.; Malysheva, A. O.; Vesnina Zh., V.; Rebrova Yu., T.; Shvera Yu., I.

В: Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost, Том 40, № 2, 1995, стр. 6-9.

Результат исследований: Материалы для журналаСтатья

Lishmanov Yu., B, Chernov, VI, Krivonogov, NG, Malysheva, AO, Vesnina Zh., V, Rebrova Yu., T & Shvera Yu., I 1995, 'Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard', Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost, том. 40, № 2, стр. 6-9.
Lishmanov Yu. B, Chernov VI, Krivonogov NG, Malysheva AO, Vesnina Zh. V, Rebrova Yu. T и соавт. Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard. Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost. 1995;40(2):6-9.
Lishmanov Yu., B. ; Chernov, V. I. ; Krivonogov, N. G. ; Malysheva, A. O. ; Vesnina Zh., V. ; Rebrova Yu., T. ; Shvera Yu., I. / Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard. В: Meditsinskaya Radiologiya i Radiatsionnaya Bezopasnost. 1995 ; Том 40, № 2. стр. 6-9.
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abstract = "Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of 199Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.",
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T1 - Experimental pharmacokinetic and scintigraphic studies of 99mTc-techmicard

AU - Lishmanov Yu., B.

AU - Chernov, V. I.

AU - Krivonogov, N. G.

AU - Malysheva, A. O.

AU - Vesnina Zh., V.

AU - Rebrova Yu., T.

AU - Shvera Yu., I.

PY - 1995

Y1 - 1995

N2 - Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of 199Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.

AB - Pharmacokinetic and scintigraphic studies of a radiopharmaceutical for perfusion scintigraphy of the myocardium, 99mTc-techmikard, were carried out in 40 rats and 8 rabbits. pharmacokinetic characteristics of the agent prepared on the basis extraction stationary or absorption Tc generators were found Identical. Despite the fact that the pharmacokinetics of this agent differs from of 199Tl, its rapid clearance from the blood, high factor of extraction the myocardium, and a sufficiently high ratio of the heart to background activities of the radiopharmaceutical permit high-quality imaging of the myocardium in experimental animals. The conditions of the sterilization and three-hour storage after preparation of solution do influence its pharmacokinetics or quality of scintigrams.

KW - Tc-techmicard imaging

KW - Myocardium

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