Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme

V. R. Muzykantov, E. A. Puchnina, Elena Nikolaevna Atochina, H. Hiemish, M. A. Slinkin, F. E. Meertsuk, S. M. Danilov

Результат исследований: Материалы для журналаСтатья

30 Цитирования (Scopus)

Выдержка

The biodistribution of radiolabeled monoclonal antibody (Mab) to angiotensin-converting enzyme (ACE) was examined in normal and endotoxin-treated rats. Endotoxin administration at a dose of 4 mg/kg induced mild or middle pulmonary edema. The ACE activity in lung homogenate remained virtually unchanged, while the activity of serum ACE increased 15 hr after endotoxin infusion. In normal rats, anti-ACE Mab accumulates specifically in the lung after i.v. injection. Endotoxin injection induces reduction of specific pulmonary uptake of this antibody. Even in nonedematous endotoxemia, the accumulation of anti-ACE Mab antibody (Mab 9B9) decreased from 19.02 to 11.91% of ID/g of tissue without any change in accumulation of control nonspecific IgG. The antibody distribution in other organs and its blood level were almost the same as in the control. In a case of endotoxemia accompanied by increased microvascular permeability, the lung accumulation of Mab 9B9 was reduced to 9.17% of ID/g of tissue, while the accumulation of nonspecific IgG increased to 1.44% versus 0.89% in the control.

Язык оригиналаАнглийский
Страницы (с-по)453-460
Число страниц8
ЖурналJournal of Nuclear Medicine
Том32
Номер выпуска3
СостояниеОпубликовано - 1991
Опубликовано для внешнего пользованияДа

Отпечаток

Peptidyl-Dipeptidase A
Endotoxins
Monoclonal Antibodies
Lung
Endotoxemia
Antibodies
Immunoglobulin G
Injections
Capillary Permeability
Pulmonary Edema
Serum

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Цитировать

Muzykantov, V. R., Puchnina, E. A., Atochina, E. N., Hiemish, H., Slinkin, M. A., Meertsuk, F. E., & Danilov, S. M. (1991). Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme. Journal of Nuclear Medicine, 32(3), 453-460.

Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme. / Muzykantov, V. R.; Puchnina, E. A.; Atochina, Elena Nikolaevna; Hiemish, H.; Slinkin, M. A.; Meertsuk, F. E.; Danilov, S. M.

В: Journal of Nuclear Medicine, Том 32, № 3, 1991, стр. 453-460.

Результат исследований: Материалы для журналаСтатья

Muzykantov, VR, Puchnina, EA, Atochina, EN, Hiemish, H, Slinkin, MA, Meertsuk, FE & Danilov, SM 1991, 'Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme', Journal of Nuclear Medicine, том. 32, № 3, стр. 453-460.
Muzykantov, V. R. ; Puchnina, E. A. ; Atochina, Elena Nikolaevna ; Hiemish, H. ; Slinkin, M. A. ; Meertsuk, F. E. ; Danilov, S. M. / Endotoxin reduces specific pulmonary uptake of radiolabeled monoclonal antibody to angiotensin-converting enzyme. В: Journal of Nuclear Medicine. 1991 ; Том 32, № 3. стр. 453-460.
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abstract = "The biodistribution of radiolabeled monoclonal antibody (Mab) to angiotensin-converting enzyme (ACE) was examined in normal and endotoxin-treated rats. Endotoxin administration at a dose of 4 mg/kg induced mild or middle pulmonary edema. The ACE activity in lung homogenate remained virtually unchanged, while the activity of serum ACE increased 15 hr after endotoxin infusion. In normal rats, anti-ACE Mab accumulates specifically in the lung after i.v. injection. Endotoxin injection induces reduction of specific pulmonary uptake of this antibody. Even in nonedematous endotoxemia, the accumulation of anti-ACE Mab antibody (Mab 9B9) decreased from 19.02 to 11.91{\%} of ID/g of tissue without any change in accumulation of control nonspecific IgG. The antibody distribution in other organs and its blood level were almost the same as in the control. In a case of endotoxemia accompanied by increased microvascular permeability, the lung accumulation of Mab 9B9 was reduced to 9.17{\%} of ID/g of tissue, while the accumulation of nonspecific IgG increased to 1.44{\%} versus 0.89{\%} in the control.",
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AU - Atochina, Elena Nikolaevna

AU - Hiemish, H.

AU - Slinkin, M. A.

AU - Meertsuk, F. E.

AU - Danilov, S. M.

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