Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: A possible mechanism

A. V. Krylatov, R. V. Uzhachenko, L. N. Maslov, N. A. Bernatskaya, A. Makriyannis, R. Mechoulam, R. G. Pertwee, O. M. Sal'nikova, J. B. Stefano, Yu B. Lishmanov

Результат исследований: Материалы для журналаСтатья

22 Цитирования (Scopus)

Аннотация

Stimulation of cannabinoid receptors with endogenous cannabinoid anandamide and its enzyme-resistant analogue R-(+)-methanandamide improved cardiac resistance to arrhythmias induced by coronary occlusion and reperfusion. This antiarrhythmic effect was not associated with activation of NO synthase, since pretreatment with NG-nitro-L-arginine methyl ester had no effect on the incidence of ischemia/reperfusion-induced arrhythmias. Blockade of ATP-dependent K+ channels with glybenclamide did not abolish the antiarrhythmic effect of R-(+)-methanandamide. Antiarrhythmic activity of endogenous cannabinoids is probably associated with their direct effects on the myocardium.

Язык оригиналаАнглийский
Страницы (с-по)122-124
Число страниц3
ЖурналBulletin of Experimental Biology and Medicine
Том133
Номер выпуска2
DOI
СостояниеОпубликовано - 26 авг 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Цитировать

    Krylatov, A. V., Uzhachenko, R. V., Maslov, L. N., Bernatskaya, N. A., Makriyannis, A., Mechoulam, R., Pertwee, R. G., Sal'nikova, O. M., Stefano, J. B., & Lishmanov, Y. B. (2002). Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: A possible mechanism. Bulletin of Experimental Biology and Medicine, 133(2), 122-124. https://doi.org/10.1023/A:1015574100494