Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon

I. A. Khlusov, E. V. Kibler, V. L. Kudryavtseva, S. I. Tverdokhlebov, E. N. Bolbasov, V. V. Botvin, A. D. Latypov, N. D. Gazatova, L. S. Litvinova, V. M. Buznik, E. L. Choynzonov

Результат исследований: Материалы для журналаСтатья

Аннотация

Abstract: The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-α-2b (IFNα-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFNα-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.

Язык оригиналаАнглийский
Страницы (с-по)74-78
Число страниц5
ЖурналDoklady Chemistry
Том484
Номер выпуска2
DOI
СостояниеОпубликовано - 1 авг 2019

ASJC Scopus subject areas

  • Chemistry(all)

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