Electrochemical determination of heparin in pharmaceuticals with using malachite green

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

1 Цитирования (Scopus)

Аннотация

In this paper for determination of heparin in pharmaceuticals by constant-current sweep voltammetry on the mercury-film electrode (MFE) we used cationic malachite green (MG) dye which is capable to form a complex with heparin. In the 0.05 M potassium tetraoxalate (KH3C4O8 · 2H2O) buffer solution with pH 1.65 MG had a well-defined peak of electroreduction at -0.46 V (vs. CSE). During the study of electrochemical properties of heparin in complex with MG in cathodic potential range from 0.0 V to -1.3 V on MFE besides the signal from the dye at E = - 0.46 V the second signal at E = –0.87 V was found. Increasing the concentration of heparin in the solution led to decrease of signal intensity at E = -0.87 V. Optimum conditions for the electrochemical determination of heparin in dosage form with using MG were picked up. Influence of auxiliary components of heparin pharmacological solution on electroreduction of the complex MG-Hep was investigated. Under optimal conditions the decrease of reduction peak currents at E = -0.87 V was proportional to heparin concentration in the range from 3.9 · 10-4 mg/ml to 3.9 · 10-3 mg/ml.

Язык оригиналаАнглийский
Название основной публикацииAdvanced Materials Research
ИздательTrans Tech Publications Ltd
Страницы292-296
Число страниц5
Том1040
ISBN (печатное издание)9783038352648
DOI
СостояниеОпубликовано - 2014
СобытиеInternational Conference for Young Scientists “High Technology: Research and Applications 2014”, HTRA 2014 - Tomsk, Российская Федерация
Продолжительность: 26 мар 201428 мар 2014

Серия публикаций

НазваниеAdvanced Materials Research
Том1040
ISSN (печатное издание)10226680
ISSN (электронное издание)16628985

Другое

ДругоеInternational Conference for Young Scientists “High Technology: Research and Applications 2014”, HTRA 2014
СтранаРоссийская Федерация
ГородTomsk
Период26.3.1428.3.14

ASJC Scopus subject areas

  • Engineering(all)

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