Effect of the porosity, roughness, wettability, and charge of micro-arc coatings on the efficiency of doxorubicin delivery and suppression of cancer cells

Mariya Borisovna Sedelnikova, Ekaterina G. Komarova, Yurii P. Sharkeev, Valentina V. Chebodaeva, Tatiana V. Tolkacheva, Anastasia M. Kondranova, Alexander M. Zakharenko, Olga V. Bakina

Результат исследований: Материалы для журналаСтатья

Аннотация

Porous calcium phosphate coatings were formed by the micro-arc oxidation method on the surface of titanium for the loading and controlled release of the anticancer drug doxorubicin. The coatings' morphology and microstructure were examined by scanning electron microscopy. The phase composition was determined with the help of X-ray diffraction analysis. Studies of the hydrophilic properties of the coatings and their zeta potential were carried out. Data on the kinetics of doxorubicin adsorption-desorption were obtained. In addition, the effect of calcium phosphate coatings impregnated with doxorubicin on the viability of the Neuro-2a cell line was revealed. The coating formed at low voltages of 200-250 V contained a greater number of branched communicating pores, and therefore they were able to adsorb a greater amount of doxorubicin. The surface charge also contributes to the process of the adsorption-desorption of doxorubicin, but this effect is not fully understood and further studies are required to identify it.

Язык оригиналаАнглийский
Номер статьи664
ЖурналCoatings
Том10
Номер выпуска7
DOI
СостояниеОпубликовано - 1 июл 2020

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry

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  • Цитировать

    Sedelnikova, M. B., Komarova, E. G., Sharkeev, Y. P., Chebodaeva, V. V., Tolkacheva, T. V., Kondranova, A. M., Zakharenko, A. M., & Bakina, O. V. (2020). Effect of the porosity, roughness, wettability, and charge of micro-arc coatings on the efficiency of doxorubicin delivery and suppression of cancer cells. Coatings, 10(7), [664]. https://doi.org/10.3390/coatings10070664