Выдержка
Surface modification of bioresorbable polymer material (polycaprolactone, PCL) with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target was investigated. Plasma treatment resulted in an increase of surface roughness of PCL, crystallite size, the surface free energy and hydrophilicity. Increased treatment time (30, 60, 150 seconds) provoked the polymer surface saturation with the sputtering target ions (calcium, phosphorus). The assessment of plasma exposure of PCL surface on bone marrow multipotent mesenchymal stromal cells behavior (BM MSCs) has been performed. Modification of the polymer surface with the abnormal glow discharge stimulated adhesion and subsequent proliferation of BM MSCs; thus, maximum values were achieved with the surface treatment for 60 s. This type of plasma modification did not affect cell viability (apoptosis, necrosis). Thus, the surface modification with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target, appear to be a promising method of surface modification of bioresorbable polymer material (PCL) for tissue engineering.
| Язык оригинала | Английский |
|---|---|
| Страницы (с-по) | 56-63 |
| Число страниц | 8 |
| Журнал | Biomeditsinskaya Khimiya |
| Том | 62 |
| Номер выпуска | 1 |
| DOI | |
| Состояние | Опубликовано - 1 янв 2016 |
Отпечаток
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Цитировать
Effect of radio frequency discharge plasma on surface properties and biocompatibility of polycaprolactone matrices. / Bolbasov, E. N.; Antonova, L. V.; Matveeva, V. G.; Novikov, V. A.; Shesterikov, Evgeniy Viktorovich; Bogomolova, N. L.; Golovkin, A. S.; Tverdokhlebov, Sergey Ivanovich; Barbarash, O. L.; Barbarash, L. S.
В: Biomeditsinskaya Khimiya, Том 62, № 1, 01.01.2016, стр. 56-63.Результат исследований: Материалы для журнала › Статья
}
TY - JOUR
T1 - Effect of radio frequency discharge plasma on surface properties and biocompatibility of polycaprolactone matrices
AU - Bolbasov, E. N.
AU - Antonova, L. V.
AU - Matveeva, V. G.
AU - Novikov, V. A.
AU - Shesterikov, Evgeniy Viktorovich
AU - Bogomolova, N. L.
AU - Golovkin, A. S.
AU - Tverdokhlebov, Sergey Ivanovich
AU - Barbarash, O. L.
AU - Barbarash, L. S.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Surface modification of bioresorbable polymer material (polycaprolactone, PCL) with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target was investigated. Plasma treatment resulted in an increase of surface roughness of PCL, crystallite size, the surface free energy and hydrophilicity. Increased treatment time (30, 60, 150 seconds) provoked the polymer surface saturation with the sputtering target ions (calcium, phosphorus). The assessment of plasma exposure of PCL surface on bone marrow multipotent mesenchymal stromal cells behavior (BM MSCs) has been performed. Modification of the polymer surface with the abnormal glow discharge stimulated adhesion and subsequent proliferation of BM MSCs; thus, maximum values were achieved with the surface treatment for 60 s. This type of plasma modification did not affect cell viability (apoptosis, necrosis). Thus, the surface modification with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target, appear to be a promising method of surface modification of bioresorbable polymer material (PCL) for tissue engineering.
AB - Surface modification of bioresorbable polymer material (polycaprolactone, PCL) with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target was investigated. Plasma treatment resulted in an increase of surface roughness of PCL, crystallite size, the surface free energy and hydrophilicity. Increased treatment time (30, 60, 150 seconds) provoked the polymer surface saturation with the sputtering target ions (calcium, phosphorus). The assessment of plasma exposure of PCL surface on bone marrow multipotent mesenchymal stromal cells behavior (BM MSCs) has been performed. Modification of the polymer surface with the abnormal glow discharge stimulated adhesion and subsequent proliferation of BM MSCs; thus, maximum values were achieved with the surface treatment for 60 s. This type of plasma modification did not affect cell viability (apoptosis, necrosis). Thus, the surface modification with abnormal glow discharge, initiated during radio-frequency magnetron sputtering of a hydroxyapatite target, appear to be a promising method of surface modification of bioresorbable polymer material (PCL) for tissue engineering.
KW - Biocompatibility
KW - Free energy
KW - Hydrophilicity
KW - Polycaprolactone
KW - Roughness
KW - Surface modification
UR - http://www.scopus.com/inward/record.url?scp=84974661244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84974661244&partnerID=8YFLogxK
U2 - 10.18097/PBMC20166201056
DO - 10.18097/PBMC20166201056
M3 - Article
C2 - 26973188
AN - SCOPUS:84974661244
VL - 62
SP - 56
EP - 63
JO - Biomeditsinskaya Khimiya
JF - Biomeditsinskaya Khimiya
SN - 2310-6905
IS - 1
ER -