Effect of polylactide molecular weight on doxorubicin and temozolomide release from chitosan-grafted polylactide nanoparticles

Antonio Di Martino, Pavel Kucharczyk, Vladimir Sedlarik

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Аннотация

The purpose of this study was to examine low molecular weight chitosan-grafted polylactide nanoparticles as a drug delivery system for doxorubicin and temozolomide. We investigated the effect of polylactide molecular weight on the release kinetic and encapsulation efficiency of both drugs. Polylactide (10 kDa and 60 kDa) has been linked to chitosan via coupling reaction. Chitosan-grafted-polylactide nanoparticles were prepared via ionotropic gelation method with tripolyphosphate as a linking agent. Results such as size (150-350 nm), -potential (+25-35 mV), efficient encapsulation and prolonged release kinetic suggested that chitosan-grafted-poly lactic acid could be a great system for co-delivery of doxorubicin and temozolomide in Glioblastoma Multiforme treatment.

Язык оригиналаАнглийский
Название основной публикацииNANOCON 2013 - Conference Proceedings, 5th International Conference
ИздательTANGER Ltd.
Страницы521-526
Число страниц6
ISBN (электронное издание)9788087294475
СостояниеОпубликовано - 1 янв 2013
Опубликовано для внешнего пользованияДа
Событие5th International Conference NANOCON 2013 - Brno, Чешская Республика
Продолжительность: 16 окт 201318 окт 2013

Серия публикаций

НазваниеNANOCON 2013 - Conference Proceedings, 5th International Conference

Конференция

Конференция5th International Conference NANOCON 2013
СтранаЧешская Республика
ГородBrno
Период16.10.1318.10.13

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications
  • Materials Science(all)

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  • Цитировать

    Di Martino, A., Kucharczyk, P., & Sedlarik, V. (2013). Effect of polylactide molecular weight on doxorubicin and temozolomide release from chitosan-grafted polylactide nanoparticles. В NANOCON 2013 - Conference Proceedings, 5th International Conference (стр. 521-526). (NANOCON 2013 - Conference Proceedings, 5th International Conference). TANGER Ltd..