Vliianie proizvodnykh platiny na aktivnost' mikrosomnykh NADPH-oksidoreduktaz.

I. A. Shchepetkin, V. M. Plotnikov, V. T. Kagiia

Результат исследований: Материалы для журналаСтатья

Аннотация

The influence of platinum derivatives, cisplatin (cis-diamminedichloroplatinum) and imidazolplatin (cis-diimidazoledichloroplatinum) on the activity of rat liver microsomal NADPH-oxidoreductases was investigated in vitro using spectrophotometrical and chemiluminometrical methods. In the range of concentrations from 1 to 12 microM cisplatin inhibited NADPH-cytochrome c-reductase activity and NADPH/lucigenin-dependent chemiluminescence of microsomes. The 3 microM cisplatin decreased the NADPH-dependent reductase activity by 50%. At concentrations less than 2.5 mM sanazole (drug AK-2123) did not prevent the inhibiting influence of cisplatin on microsomal NADPH-dependent reductases. Imidazolplatin insignificantly inhibited NADPH-reductases. It is concluded that negligible inhibiting effect of imidazolplatin on microsomal NADPH-oxidoreductase allows us to consider this platinum derivative as a promising compound for further experimental trials as anticancer drug with low toxic action on the normal tissues of an organism.

Переведенное названиеEffect of platinum derivatives on microsomal NADPH-oxidoreductase activity
Язык оригиналаРусский
Страницы (с-по)373-381
Число страниц9
ЖурналVoprosy Meditsinskoj Khimii
Том47
Номер выпуска4
СостояниеОпубликовано - июл 2001
Опубликовано для внешнего пользованияДа

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry
  • Molecular Biology
  • Biotechnology
  • Pharmacology

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