Effect of enkephalins on the synthesis of myocardial proteins during acute cold exposure

Yu B. Lishmanov, N. V. Naryznaya, L. N. Maslov

Результат исследований: Материалы для журналаСтатья

Выдержка

Acute cold exposure of organism (4 hours at -20°C) inhibits myocardial protein syntesis and increases cortisol/insulin index in rat blood. Preliminary repeated administration in [D-Ala2, Leu5,Arg6]-enkephalin (dalargin) prevents the decrease of myocardial protein synthesis rate after cold stress and dicreases cortisol/insulin ratio. Pretreatment with naloxone at dose of 0.2 mg/kg or 2 mg/kg doesn't eliminate "anabolic" effect of dalargin. "Anabolic" effect of dalargin is suggested to be connected with -opioid receptor stimulation and change in insulin and cortisol secretion.

Язык оригиналаАнглийский
Страницы (с-по)230-231
Число страниц2
ЖурналVoprosy Meditsinskoj Khimii
Том45
Номер выпуска3
СостояниеОпубликовано - 1999

Отпечаток

Enkephalins
Hydrocortisone
Anabolic Agents
Insulin
Proteins
Opioid Receptors
Naloxone
Rats
Blood

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Clinical Biochemistry
  • Molecular Biology
  • Pharmacology

Цитировать

Effect of enkephalins on the synthesis of myocardial proteins during acute cold exposure. / Lishmanov, Yu B.; Naryznaya, N. V.; Maslov, L. N.

В: Voprosy Meditsinskoj Khimii, Том 45, № 3, 1999, стр. 230-231.

Результат исследований: Материалы для журналаСтатья

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