Effect of enkephalins on the synthesis of myocardial proteins during acute cold exposure

Yu B. Lishmanov, N. V. Naryznaya, L. N. Maslov

Результат исследования: Материалы для журналаСтатья

Аннотация

Acute cold exposure of organism (4 hours at -20°C) inhibits myocardial protein syntesis and increases cortisol/insulin index in rat blood. Preliminary repeated administration in [D-Ala2, Leu5,Arg6]-enkephalin (dalargin) prevents the decrease of myocardial protein synthesis rate after cold stress and dicreases cortisol/insulin ratio. Pretreatment with naloxone at dose of 0.2 mg/kg or 2 mg/kg doesn't eliminate "anabolic" effect of dalargin. "Anabolic" effect of dalargin is suggested to be connected with -opioid receptor stimulation and change in insulin and cortisol secretion.

Язык оригиналаАнглийский
Страницы (с... по...)230-231
Количество страниц2
ЖурналVoprosy Meditsinskoj Khimii
Том45
Номер выпуска3
Статус публикацииОпубликовано - 1999

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Clinical Biochemistry
  • Molecular Biology
  • Pharmacology

Цитировать