Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice

K. A. Lopatina, E. A. Safonova, K. V. Nevskaya, M. N. Stakheeva, A. M. Gur’ev, E. P. Zueva, T. G. Razina, E. N. Amosova, S. G. Krylov, M. V. Belousov

Результат исследований: Материалы для журналаСтатья

2 Цитирования (Scopus)

Аннотация

Tumor cells can maintain their growth via immunosuppression and escape from host antitumor immunity by controlling the PD-1/PD-L1 system. Expression of PD-L1 (CD274) is an inhibitory signal for T cells, while the increase in CD326 expression in the tumor tissue correlates with metastasis development. The experimental preparation on the basis of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan from Acorus calamus L. produces an antitumor effect: it reduces tumor node size and the number and area of metastases after transplantation of Lewis lung carcinoma. Using flow cytometry, we demonstrated a decrease in the population of tumor cells expressing surface CD274 (PD-L1) and CD326 antigens after 20-day course of α(1,2)-L-rhamno-α(1,4)-D-galactopyranosyluronan.

Язык оригиналаАнглийский
Страницы (с-по)102-105
Число страниц4
ЖурналBulletin of Experimental Biology and Medicine
Том164
Номер выпуска1
DOI
СостояниеОпубликовано - 1 ноя 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Подробные сведения о темах исследования «Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать

    Lopatina, K. A., Safonova, E. A., Nevskaya, K. V., Stakheeva, M. N., Gur’ev, A. M., Zueva, E. P., Razina, T. G., Amosova, E. N., Krylov, S. G., & Belousov, M. V. (2017). Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice. Bulletin of Experimental Biology and Medicine, 164(1), 102-105. https://doi.org/10.1007/s10517-017-3934-4