Effect of a novel load-bearing trabecular Nitinol scaffold on rabbit radius bone regeneration

Irena Gotman, Asaph Zaretzky, Sergey G. Psakhie, Elazar Y. Gutmanas

Результат исследований: Материалы для книги/типы отчетовМатериалы для конференции

Аннотация

The research aim was to evaluate the bone regeneration capability of novel load-bearing NiTi alloy (Nitinol) scaffolds in a critical-size defect (CSD) model. High strength "trabecular Nitinol" scaffolds were prepared by PIRAC (Powder Immersion Reaction Assisted Coating) annealing of the highly porous Ni foam in Ti powder at 900°C. This was followed by PIRAC nitriding to mitigate the release of potentially toxic Ni ions. Scaffolds phase composition and microstructure were characterized by X-ray diffraction and scanning electron microscopy (SEM/EDS), and their mechanical properties were tested in compression. New Zealand white rabbits received bone defect in right radius and were divided in four groups randomly. In the control group, nothing was placed in the defect. In other groups, NiTi scaffolds were implanted in the defect: (i) as produced, (ii) loaded with bone marrow aspirate (BMA), and (iii) biomimetically CaP-coated. The animals were sacrificed after 12 weeks. The forelimbs with scaffolds were resected, fixed, sectioned and examined in SEM. New bone formation inside the scaffold was studied by EDS analysis and by the processing of backscattered electron images. Bone ingrowth into the scaffold was observed in all implant groups, mostly next to the ulna. New bone formation was strongly enhanced by BMA loading and biomimeatic CaP coating, the bone penetrating as much as 1-1.5 mm into the scaffold. The results of this preliminary study demonstrate that the newly developed high strength trabecular Nitinol scaffolds can be successfully used for bone regeneration in critical size defects.

Язык оригиналаАнглийский
Название основной публикацииAdvanced Materials with Hierarchical Structure for New Technologies and Reliable Structures
ИздательAmerican Institute of Physics Inc.
Том1683
ISBN (электронное издание)9780735413306
DOI
СостояниеОпубликовано - 27 окт 2015
СобытиеInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015 - Tomsk, Российская Федерация
Продолжительность: 21 сен 201525 сен 2015

Конференция

КонференцияInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015
СтранаРоссийская Федерация
ГородTomsk
Период21.9.1525.9.15

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Fingerprint Подробные сведения о темах исследования «Effect of a novel load-bearing trabecular Nitinol scaffold on rabbit radius bone regeneration». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать

    Gotman, I., Zaretzky, A., Psakhie, S. G., & Gutmanas, E. Y. (2015). Effect of a novel load-bearing trabecular Nitinol scaffold on rabbit radius bone regeneration. В Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures (Том 1683). [020243] American Institute of Physics Inc.. https://doi.org/10.1063/1.4932933