Diuretic activity of 4-O-Carboxyphenyl-D-Glucopyranoside sodium salt administered via different routes

I. V. Smirnov, T. O. Murashko, A. A. Ivanov, A. O. Nemtsev, P. S. Postnikov, A. A. Bondarev, V. V. Udut

Результат исследований: Материалы для журналаСтатья

Аннотация

It was compared the diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 nmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.

Язык оригиналаАнглийский
Страницы (с-по)20-22
Число страниц3
ЖурналEksperimental'naya i Klinicheskaya Farmakologiya
Том79
Номер выпуска1
СостояниеОпубликовано - 1 янв 2016

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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